The immunology of asymptomatic SARS-CoV-2 infection: what are the key questions?

被引：70

作者：

Boyton, Rosemary J. ^{[1
,2
]}

Altmann, Daniel M. ^{[3
]}

机构：

[1] Imperial Coll London, Fac Med, Dept Infect Dis, London, England

[2] Guys & St Thomas NHS Fdn Trust, Royal Brompton & Harefield Hosp, Lung Div, London, England

[3] Imperial Coll London, Fac Med, Dept Immunol & Inflammat, London, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2021年 / 21卷 / 12期

基金：

欧盟地平线“2020”; 英国医学研究理事会; “创新英国”项目; 美国国家卫生研究院;

关键词：

COVID-19; TRANSMISSION; SARS;

D O I：

10.1038/s41577-021-00631-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An important challenge during the COVID-19 pandemic has been to understand asymptomatic disease and the extent to which this may be a source of transmission. As asymptomatic disease is by definition hard to screen for, there is a lack of clarity about this aspect of the COVID-19 spectrum. Studies have considered whether the prevalence of asymptomatic disease is determined by differences in age, demographics, viral load, duration of shedding, and magnitude or durability of immunity. It is clear that adaptive immunity is strongly activated during asymptomatic infection, but some features of the T cell and antibody response may differ from those in symptomatic disease. Areas that need greater clarity include the extent to which asymptomatic disease leads to persistent symptoms (long COVID), and the quality, quantity and durability of immune priming required to confer subsequent protection.

引用

页码：762 / 768

页数：7

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