Monolayer detection of biochemical agents using etched-core fiber Bragg grating sensors

被引：35

作者：

Saini, S. S.

Stanford, C.

Lee, S. M.

Park, J.

DeShong, R.

Bentley, W. E.

Dagenais, M. ^{[1
]}

机构：

[1] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA

[2] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

[3] Univ Maryland, Dept Bioengn, College Pk, MD 20742 USA

来源：

IEEE PHOTONICS TECHNOLOGY LETTERS | 2007年 / 19卷 / 17-20期

关键词：

biological sensor; chemical sensor; evanescent field; fiber Bragg grating (FBG); monolayer detection;

D O I：

10.1109/LPT.2007.902345

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

It is demonstrated that the etched-core fiber Bragg grating sensor can be used to detect down to a monolayer of biological and chemical agents immobilized on the surface of the fiber. Theoretical models based on calculating the effective index of the surrounding medium in the presence of immobilized layer(s) were developed and confirmed experimentally by immobilizing a monolayer of 3-aminopropyl-monoethoxydimethyl-silane (APMDS) and polymers of 3-aminopropyl-triethoxysilane (APTES) on the surface of the fiber. The immobilization of APMDS and APTES is confirmed by carrying out hybridization of DNA. We also demonstrate that the sensor can be used to understand and optimize biological and chemical processes.

引用

页码：1341 / 1343

页数：3

共 6 条

[1] Determination of the main forces driving DNA oligonucleotide adsorption onto aminated silica wafers [J].