Neural Crossroads in the Hematopoietic Stem Cell Niche

被引：32
作者：
Agarwala, Sobhika [1 ]
Tamplin, Owen J. [1 ]
机构：
[1] Univ Illinois, Dept Pharmacol, Coll Med, Ctr Stem Cell & Regenerat Med, Chicago, IL 60612 USA
来源：
TRENDS IN CELL BIOLOGY | 2018年 / 28卷 / 12期
基金：
美国国家卫生研究院;
关键词：
MARROW STROMAL CELLS; TYROSINE KINASE JAK2; BONE-MARROW; PROGENITOR CELLS; AORTIC ENDOTHELIUM; CIRCADIAN-RHYTHMS; NERVE-TERMINALS; MOBILIZATION; INNERVATION; MUTATION;
D O I：
10.1016/j.tcb.2018.05.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The hematopoietic stem cell (HSC) niche supports steady-state hematopoiesis and responds to changing needs during stress and disease. The nervous system is an important regulator of the niche, and its influence is established early in development when stem cells are specified. Most research has focused on direct innervation of the niche, however recent findings show there are different modes of neural control, including globally by the central nervous system (CNS) and hormone release, locally by neural crest-derived mesenchymal stem cells, and intrinsically by hematopoietic cells that express neural receptors and neurotransmitters. Dysregulation between neural and hematopoietic systems can contribute to disease, however new therapeutic opportunities may be found among neuroregulator drugs repurposed to support hematopoiesis.
引用
收藏
页码：987 / 998
页数：12
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