The role of the central nucleus of the amygdala in nociception and aversion

被引：25

作者：

Finn, DP ^{[1
]}

Chapman, V ^{[1
]}

Jhaveri, MD ^{[1
]}

Samanta, S ^{[1
]}

Manders, T ^{[1
]}

Bowden, J ^{[1
]}

Matthews, L ^{[1
]}

Marsden, CA ^{[1
]}

Beckett, SRG ^{[1
]}

机构：

[1] Univ Nottingham, Sch Med, Inst Neurosci, Sch Biomed Sci,Queens Med Ctr, Nottingham NG7 2UH, England

来源：

NEUROREPORT | 2003年 / 14卷 / 07期

关键词：

amygdala; aversion; calcium channels; omega-conotoxin; fear; formalin test; GVIA; pain; rat; ultrasound;

D O I：

10.1097/01.wnr.0000069062.85441.29

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of the central nucleus of the amygdala in nociception conditioned and unconditioned aversion - was studied. Rats received microinjection of vehicle or the N-type Ca2+ channel blocker omega-conotoxin GVIA (0.2 mug/250 nl) into the central amygdaloid nucleus prior to intra-plantar injection of formalin, ultrasound exposure or immediately prior to the acquisition phase of an aversive conditioning trial. Intra-amygdala omega-conotoxin GVIA resulted in an earlier onset of nociceptive response to formalin and increased nociceptive behaviour during the first 5 min. omega-Conotoxin GVIA significantly reduced conditioned freezing behaviour with no effect on ultrasound-induced unconditioned aversive behaviour. These data indicate that N-type Ca2+ channels in the central amygdaloid nucleus play a role in mediating behavioural responses to nociceptive and conditioned aversive stimuli.

引用

页码：981 / 984

页数：4

共 26 条

[1] Different lateral amygdala outputs mediate reactions and actions elicited by a fear-arousing stimulus [J].