Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture

被引：37

作者：

Lunemann, Sebastian ^{[1
]}

Schoebel, Anja ^{[2
]}

Kah, Janine ^{[3
]}

Fittje, Pia ^{[1
]}

Hoelzemer, Angelique ^{[1
,4
,5
]}

Langeneckert, Annika E. ^{[1
]}

Hess, Leonard U. ^{[1
]}

Poch, Tobias ^{[3
]}

Martrus, Gloria ^{[1
,5
]}

Garcia-Beltran, Wilfredo F. ^{[6
]}

Koerner, Christian ^{[1
]}

Ziegler, Annerose E. ^{[1
]}

Richert, Laura ^{[1
,7
]}

Oldhafer, Karl J. ^{[8
]}

zur Wiesch, Julian Schulze ^{[4
]}

Schramm, Christoph ^{[3
]}

Dandri, Maura ^{[3
]}

Herker, Eva ^{[2
]}

Altfeld, Marcus ^{[1
,5
,9
]}

机构：

[1] Leibniz Inst Expt Virol, Heinrich Pette Inst, Dept Virus Immunol, Martinistr 52, D-20251 Hamburg, Germany

[2] Leibniz Inst Expt Virol, Heinrich Pette Inst, Jr Res Grp HCV Replicat, Hamburg, Germany

[3] Univ Med Ctr Hamburg Eppendorf, Ctr Internal Med, Dept Med 1, Hamburg, Germany

[4] Univ Med Ctr Hamburg Eppendorf, Infect Dis Sect, Dept Med 1, Hamburg, Germany

[5] Partner Site Hamburg Lubeck Borstel Riems, German Ctr Infect Res DZIF, Hamburg, Germany

[6] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA

[7] Bordeaux Univ, INRIA SISTM, INSERM, U1219, Bordeaux, France

[8] Semmelweis Univ Med, Asklepios Hosp Barmbek, Dept Gen & Abdominal Surg, Asklepios Campus, Hamburg, Germany

[9] Univ Med Ctr Hamburg Eppendorf, Inst Immunol, Hamburg, Germany

来源：

GASTROENTEROLOGY | 2018年 / 155卷 / 05期

关键词：

Antiviral Immune Response; Regulation; Immunity; Human Leukocyte Antigen; C-VIRUS-INFECTION; HEPATOCELLULAR-CARCINOMA; RECEPTOR; EXPRESSION; RESPONSES; LIGANDS;

D O I：

10.1053/j.gastro.2018.07.019

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Killer-cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer (NK) cells. Binding of KIR3DS1 to its recently discovered ligand, HLA-F, activates NK cells and has been associated with resolution of hepatitis C virus (HCV) infection. We investigated the mechanisms by which KIR3DS1 contributes to the antiviral immune response. Using cell culture systems, mice with humanized livers, and primary liver tissue from HCVinfected individuals, we found that the KIR3DS1 ligand HLA-F is up-regulated on HCV-infected cells, and that interactions between KIR3DS1 and HLA-F contribute to NK cell-mediated control of HCV. Strategies to promote interaction between KIR3DS1 and HLA-F might be developed for treatment of infectious diseases and cancer.

引用

页码：1366 / +

页数：9

共 15 条

[1] KIR3DL2 (CD158k) is a potential therapeutic target in primary cutaneous anaplastic large-cell lymphoma [J].

Battistella, M. ;

Janin, A. ;

Jean-Louis, F. ;

Collomb, C. ;

Leboeuf, C. ;

Sicard, H. ;

Bonnafous, C. ;

Dujardin, A. ;

Ram-Wolff, C. ;

Kadin, M. E. ;

Bensussan, A. ;

Bagot, M. ;

Michel, L. .

BRITISH JOURNAL OF DERMATOLOGY, 2016, 175 (02) :325-333

[2] A Phase I Trial of the Anti-KIR Antibody IPH2101 and Lenalidomide in Patients with Relapsed/Refractory Multiple Myeloma [J].

Benson, Don M., Jr. ;

Cohen, Adam D. ;

Jagannath, Sundar ;

Munshi, Nikhil C. ;

Spitzer, Gary ;

Hofmeister, Craig C. ;

Efebera, Yvonne A. ;

Andre, Pascale ;

Zerbib, Robert ;

Caligiuri, Michael A. .

CLINICAL CANCER RESEARCH, 2015, 21 (18) :4055-4061

[3] Selective export of HLA-F by its cytoplasmic tail [J].

Boyle, LH ;

Gillingham, AK ;

Munro, S ;

Trowsdale, J .

JOURNAL OF IMMUNOLOGY, 2006, 176 (11) :6464-6472

[4] Natural killer cell immunotherapies against cancer: checkpoint inhibitors and more [J].

Chiossone, Laura ;

Vienne, Margaux ;

Kerdiles, Yann M. ;

Vivier, Eric .

SEMINARS IN IMMUNOLOGY, 2017, 31 :55-63

[5] Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1 [J].

Garcia-Beltran, Wilfredo F. ;

Hoelzemer, Angelique ;

Martrus, Gloria ;

Chung, Amy W. ;

Pacheco, Yovana ;

Simoneau, Camille R. ;

Rucevic, Marijana ;

Lamothe-Molina, Pedro A. ;

Pertel, Thomas ;

Kim, Tae-Eun ;

Dugan, Haley ;

Alter, Galit ;

Dechanet-Merville, Julie ;

Jost, Stephanie ;

Carrington, Mary ;

Altfeld, Marcus .

NATURE IMMUNOLOGY, 2016, 17 (09) :1067-1074

[6] Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations [J].

Gonzalez-Galarza, Faviel F. ;

Takeshita, Louise Y. C. ;

Santos, Eduardo J. M. ;

Kempson, Felicity ;

Thomaz Maia, Maria Helena ;

Soares da Silva, Andrea Luciana ;

Teles e Silva, Andre Luiz ;

Ghattaoraya, Gurpreet S. ;

Alfirevic, Ana ;

Jones, Andrew R. ;

Middleton, Derek .

NUCLEIC ACIDS RESEARCH, 2015, 43 (D1) :D784-D788

[7] Innate and adaptive immune responses in HCV infections [J].

Heim, Markus H. ;

Thimme, Robert .

JOURNAL OF HEPATOLOGY, 2014, 61 :S14-S25

[8] Haem oxygenase-1 polymorphisms can affect HCV replication and treatment responses with different efficacy in humanized mice [J].

Kah, Janine ;

Volz, Tassilo ;

Luetgehetmann, Marc ;

Groth, Anne ;

Lohse, Ansgar W. ;

Tiegs, Gisa ;

Sass, Gabriele ;

Dandri, Maura .

LIVER INTERNATIONAL, 2017, 37 (08) :1128-1137

[9] HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection [J].

Khakoo, SI ;

Thio, CL ;

Martin, MP ;

Brooks, CR ;

Gao, XJ ;

Astemborski, J ;

Cheng, J ;

Goedert, JJ ;

Vlahov, D ;

Hilgartner, M ;

Cox, S ;

Little, AM ;

Alexander, GJ ;

Cramp, ME ;

O'Brien, SJ ;

Rosenberg, WMC ;

Thomas, DL ;

Carrington, M .

SCIENCE, 2004, 305 (5685) :872-874

[10]

Kurokohchi K, 1996, HEPATOLOGY, V23, P1181

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