A novel fucoidan complex-based functional beverage attenuates oral cancer through inducing apoptosis, G2/M cell cycle arrest and retarding cell migration/invasion

被引：11

作者：

Chen, Pei-Hui ^{[1
]}

Chiang, Pao-Chang ^{[2
,3
]}

Lo, Wen-Cheng ^{[4
,5
]}

Su, Chun-Wei ^{[2
,6
]}

Wu, Chia-Yu ^{[2
,7
]}

Chan, Chun-Hao ^{[2
,6
]}

Wu, Yi-Chieh ^{[8
]}

Cheng, Hsin-Chung ^{[2
,9
]}

Deng, Win-Ping ^{[2
,6
,10
,11
]}

Lin, Hsi-Kuei ^{[12
,13
]}

Peng, Bou-Yue ^{[2
,12
]}

机构：

[1] Taipei Med Univ, Wan Fang Med Ctr, Dept Dent, Taipei 116, Taiwan

[2] Taipei Med Univ, Coll Oral Med, Sch Dent, Taipei 11031, Taiwan

[3] Taipei Med Univ, Wan Fang Hosp, Dent Dept, Taipei 116, Taiwan

[4] Taipei Med Univ, Coll Med, Sch Med, Taipei 11031, Taiwan

[5] Taipei Med Univ Hosp, Dept Neurosurg, Taipei 11031, Taiwan

[6] Taipei Med Univ, Coll Oral Med, Stem Cell Res Ctr, Taipei 11031, Taiwan

[7] Taipei Med Univ Hosp, Dept Dent, Div Oral & Maxillofacial Surg, Taipei 110301, Taiwan

[8] Taipei Med Univ Hosp, Dept Dent, Div Periodont, Taipei 11031, Taiwan

[9] Taipei Med Univ Hosp, Dept Dent, Taipei 11031, Taiwan

[10] Fu Jen Catholic Univ, Grad Inst Biomed & Pharmaceut Sci, Taipei 242, Taiwan

[11] Tunghai Univ, Dept Life Sci, Taichung 407224, Taiwan

[12] Taipei Med Univ, Coll Oral Med, Sch Oral Hyg, Taipei 11031, Taiwan

[13] Taipei Med Univ, Dept Dent, Shuang Ho Hosp, New Taipei 235, Taiwan

来源：

JOURNAL OF FUNCTIONAL FOODS | 2021年 / 85卷

关键词：

Fucoidan complex; Oral cancer; Cyclins; Epithelial-mesenchymal transition; P21; SULFATED POLYSACCHARIDES; OVEREXPRESSION; ANTIOXIDANT; PROGRESSION; EXPRESSION; CARCINOMA; ACID; P21;

D O I：

10.1016/j.jff.2021.104665

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

In current study, we have investigated the anti-oral cancer effects of developed functional beverage, which integrates fucoidan complex (FC) with natural/organic ingredients including vegetable juice (V), mulberry (M) and wheatgrass (W), designated as VMW-FC cocktail. FC has been recognized as functional food with nutraceutical characteristics, other cocktail components are known to individually contain luxuriant bioactive factors including sulfated polysaccharides and polyphenols etc., exerting various curative impacts. Our results demonstrated that VMW-FC significantly inhibited oral cancer proliferation in a dose- and time-dependent manner. It also retarded cell cycle regulators (CDKs and cyclins) and upregulated cyclin-dependent kinase inhibitor p21. Additionally, VMW-FC suppressed cell migration along with inhibited EMT markers. Further, VMW-FC significantly attenuated xenograft tumor growth in NOD-SCID mice without further adverse effects. Conclusively, VMW-FC strongly inhibits oral cancer through inducing apoptosis, G2/M cell cycle arrest and reducing migration-related EMT markers, which may be primarily attributed to sulfated polysaccharides in beverage cocktail.

引用

页数：10

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