Risk Factors and Incidence of Epilepsy after Severe Traumatic Brain Injury

被引：34

作者：

Pease, Matthew ^{[1
]}

Gonzalez-Martinez, Jorge ^{[1
]}

Puccio, Ava ^{[1
]}

Nwachuku, Enyinna ^{[1
]}

Castellano, James F. ^{[2
]}

Okonkwo, David O. ^{[1
]}

Elmer, Jonathan ^{[2
,3
,4
]}

机构：

[1] Univ Pittsburgh, Dept Neurosurg, Med Ctr, Pittsburgh, PA USA

[2] Univ Pittsburgh, Dept Neurol, Med Ctr, Pittsburgh, PA USA

[3] Univ Pittsburgh, Dept Crit Care, Med Ctr, Pittsburgh, PA USA

[4] Univ Pittsburgh, Dept Emergency Med, Med Ctr, Pittsburgh, PA USA

来源：

ANNALS OF NEUROLOGY | 2022年 / 92卷 / 04期

关键词：

POSTTRAUMATIC SEIZURES; EPIDEMIOLOGY; ADULTS;

D O I：

10.1002/ana.26443

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We determined the incidence of post-traumatic epilepsy after severe traumatic brain injury. Of 392 patients surviving to discharge, cumulative incidence of post-traumatic epilepsy was 25% at 5 years and 32% at 15 years, an increase compared with historical reports. Among patients with one late seizure (>7 days post-trauma), the risk of seizure recurrence was 62% after 1 year and 82% at 10 years. Competing hazards regression identified age, decompressive hemicraniectomy, and intracranial infection as independent predictors of post-traumatic epilepsy. Patients with severe traumatic brain injury and a single late post-traumatic seizure will likely require long-term antiseizure medicines. ANN NEUROL 2022

引用

页码：663 / 669

页数：7

共 19 条

[11] Risk of seizure recurrence after the first late posttraumatic seizure [J].

Haltiner, AM ;

Temkin, NR ;

Dikmen, SS .

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, 1997, 78 (08) :835-840

[12] Post-traumatic epilepsy in adults: a nationwide register-based study [J].

Karlander, Markus ;

Ljungqvist, Johan ;

Zelano, Johan .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2021, 92 (06) :617-621

[13] Weighted comparison of two cumulative incidence functions with R-CIFsmry package [J].

Li, Jianing ;

Le-Rademacher, Jennifer ;

Zhang, Mei-Jie .

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, 2014, 116 (03) :205-214

[14] Simulation shows undesirable results for competing risks analysis with time-dependent covariates for clinical outcomes [J].

Poguntke, Inga ;

Schumacher, Martin ;

Beyersmann, Jan ;

Wolkewitz, Martin .

BMC MEDICAL RESEARCH METHODOLOGY, 2018, 18

[15] Incidence and risk factors of posttraumatic seizures following traumatic brain injury: A Traumatic Brain Injury Model Systems Study [J].

Ritter, Anne C. ;

Wagner, Amy K. ;

Fabio, Anthony ;

Pugh, Mary Jo ;

Walker, William C. ;

Szaflarski, Jerzy P. ;

Zafonte, Ross D. ;

Brown, Allen W. ;

Hammond, Flora M. ;

Bushnik, Tamara ;

Johnson-Greene, Douglas ;

Shea, Timothy ;

Krellman, Jason W. ;

Rosenthal, Joseph A. ;

Dreer, Laura E. .

EPILEPSIA, 2016, 57 (12) :1968-1977

[16] Epilepsy in adults [J].

Thijs, Roland D. ;

Surges, Rainer ;

O'Brien, Terence J. ;

Sander, Josemir W. .

LANCET, 2019, 393 (10172) :689-701

[17] Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study [J].

Tubiv, Meral A. ;

Lutkenhof, Evan ;

Blanco, Manuel Buitrago ;

McArthur, David ;

Villablanca, Pablo ;

Ellingson, Benjamin ;

Diaz-Arrastia, Ramon ;

Van Ness, Paul ;

Real, Courtney ;

Shrestha, Vikesh ;

Engel, Jerome, Jr. ;

Vespa, Paul M. ;

Agoston, Denes ;

Au, Alicia ;

Bell, Michael J. ;

Bleck, Tom ;

Branch, Craig ;

Blanco, Manuel Buitrago ;

Bullock, Ross ;

Burrows, Brian T. ;

Claassen, Jan ;

Clarke, Robert ;

Cloyd, James ;

Coles, Lisa ;

Crawford, Karen ;

Diaz-Arrastia, Ramon ;

Duncan, Dominique ;

Ellingson, Benjamin ;

Engel, Jerome ;

Foreman, Brandon ;

Galanopoulou, Aristea ;

Gilmore, Emily ;

Olli, Grohn ;

Harris, Neil ;

Hartings, Jed ;

Lawrence, Hirsch ;

Hunn, Martin ;

Jette, Nathalie ;

Johnston, Leigh ;

Jones, Nigel ;

Kanner, Andres ;

McArthur, David ;

Monti, Martin ;

Morokoff, Andrew ;

Moshe, Solomon ;

Mowrey, Wenzhu ;

O'Brien, Terence ;

O'Phelan, Kristine ;

Pitkanen, Asla ;

Raman, Rema .

NEUROBIOLOGY OF DISEASE, 2019, 123 :115-121

[18] The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies [J].

von Elm, Erik ;

Altman, Douglas G. ;

Egger, Matthias ;

Pocock, Stuart J. ;

Gotzsche, Peter C. ;

Vandenbroucke, Jan P. .

LANCET, 2007, 370 (9596) :1453-1457

[19] Clinical epidemiology of posttraumatic epilepsy in a group of Chinese patients [J].

Zhao, Yongqing ;

Wu, Huili ;

Wang, Xueling ;

Li, Jianguo ;

Zhang, Sai .

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2012, 21 (05) :322-326

← 1 2 →