Risk Factors and Incidence of Epilepsy after Severe Traumatic Brain Injury

被引：34

作者：

Pease, Matthew ^{[1
]}

Gonzalez-Martinez, Jorge ^{[1
]}

Puccio, Ava ^{[1
]}

Nwachuku, Enyinna ^{[1
]}

Castellano, James F. ^{[2
]}

Okonkwo, David O. ^{[1
]}

Elmer, Jonathan ^{[2
,3
,4
]}

机构：

[1] Univ Pittsburgh, Dept Neurosurg, Med Ctr, Pittsburgh, PA USA

[2] Univ Pittsburgh, Dept Neurol, Med Ctr, Pittsburgh, PA USA

[3] Univ Pittsburgh, Dept Crit Care, Med Ctr, Pittsburgh, PA USA

[4] Univ Pittsburgh, Dept Emergency Med, Med Ctr, Pittsburgh, PA USA

来源：

ANNALS OF NEUROLOGY | 2022年 / 92卷 / 04期

关键词：

POSTTRAUMATIC SEIZURES; EPIDEMIOLOGY; ADULTS;

D O I：

10.1002/ana.26443

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We determined the incidence of post-traumatic epilepsy after severe traumatic brain injury. Of 392 patients surviving to discharge, cumulative incidence of post-traumatic epilepsy was 25% at 5 years and 32% at 15 years, an increase compared with historical reports. Among patients with one late seizure (>7 days post-trauma), the risk of seizure recurrence was 62% after 1 year and 82% at 10 years. Competing hazards regression identified age, decompressive hemicraniectomy, and intracranial infection as independent predictors of post-traumatic epilepsy. Patients with severe traumatic brain injury and a single late post-traumatic seizure will likely require long-term antiseizure medicines. ANN NEUROL 2022

引用

页码：663 / 669

页数：7

共 19 条

[1] A population-based study of seizures after traumatic brain injuries [J].

Annegers, JF ;

Hauser, WA ;

Coan, SP ;

Rocca, WA .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (01) :20-24

[2] The quality of life of older adults with epilepsy: A systematic review [J].

Baranowski, Charlotte J. .

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2018, 60 :190-197

[3] The direct cost of epilepsy in the United States: A systematic review of estimates [J].

Begley, Charles E. ;

Durgin, Tracy L. .

EPILEPSIA, 2015, 56 (09) :1376-1387

[4] Long-term applicability of the new ILAE definition of epilepsy. Results from the PRO-LONG study [J].

Beretta, Simone ;

Carone, Davide ;

Zanchi, Clara ;

Bianchi, Elisa ;

Pirovano, Marta ;

Trentini, Claudia ;

Padovano, Giada ;

Colombo, Matteo ;

Cereda, Diletta ;

Scanziani, Sofia ;

Giussani, Giorgia ;

Gasparini, Sara ;

Bogliun, Graziella ;

Ferrarese, Carlo ;

Beghi, Ettore .

EPILEPSIA, 2017, 58 (09) :1518-1523

[5] The Epidemiology of Posttraumatic Epilepsy [J].

Christensen, Jakob .

SEMINARS IN NEUROLOGY, 2015, 35 (03) :218-222

[6] Long-term risk of epilepsy after traumatic brain injury in children and young adults: a population-based cohort study [J].

Christensen, Jakob ;

Pedersen, Marianne G. ;

Pedersen, Carsten B. ;

Sidenius, Per ;

Olsen, Jorn ;

Vestergaard, Mogens .

LANCET, 2009, 373 (9669) :1105-1110

[7] Analyzing risk factors for late posttraumatic seizures: A prospective, multicenter investigation [J].

Englander, J ;

Bushnik, T ;

Duong, TT ;

Cifu, DX ;

Zafonte, R ;

Wright, J ;

Hughes, R ;

Bergman, W .

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, 2003, 84 (03) :365-373

[8] A population-based study of risk of epilepsy after hospitalization for traumatic brain injury [J].

Ferguson, Pamela L. ;

Smith, Gigi M. ;

Wannamaker, Braxton B. ;

Thurman, David J. ;

Pickelsimer, E. Elisabeth ;

Selassie, Anbesaw W. .

EPILEPSIA, 2010, 51 (05) :891-898

[9] A review of seizures and epilepsy following traumatic brain injury [J].

Fordington, Surina ;

Manford, Mark .

JOURNAL OF NEUROLOGY, 2020, 267 (10) :3105-3111

[10] Post-traumatic hydrocephalus following decompressive hemicraniectomy: Incidence and risk factors in a prospective cohort of severe TBI patients [J].

Goldschmidt, Ezequiel ;

Deng, Hansen ;

Puccio, Ava M. ;

Okonkwo, David O. .

JOURNAL OF CLINICAL NEUROSCIENCE, 2020, 73 :85-88

← 1 2 →