Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients' Profiles With Oxaliplatin-Induced Peripheral Neuropathy

被引：6

作者：

Kerckhove, Nicolas ^{[1
,2
,3
]}

Selvy, Marie ^{[1
]}

Lambert, Celine ^{[2
]}

Gonneau, Coralie ^{[1
]}

Feydel, Gabrielle ^{[2
]}

Petorin, Caroline ^{[4
]}

Vimal-Baguet, Agnes ^{[4
]}

Melnikov, Sergey ^{[5
]}

Kullab, Sharif ^{[6
]}

Hebbar, Mohamed ^{[7
]}

Bouche, Olivier ^{[8
]}

Slimano, Florian ^{[9
]}

Bourgeois, Vincent ^{[10
]}

Lebrun-Ly, Valerie ^{[11
]}

Thuillier, Frederic ^{[11
]}

Mazard, Thibault ^{[12
]}

Tavan, David ^{[13
]}

Benmammar, Kheir Eddine ^{[14
]}

Monange, Brigitte ^{[14
]}

Ramdani, Mohamed ^{[15
]}

Pere-Verge, Denis ^{[16
]}

Huet-Penz, Floriane ^{[17
]}

Bedjaoui, Ahmed ^{[18
]}

Genty, Florent ^{[19
]}

Leyronnas, Cecile ^{[20
]}

Busserolles, Jerome ^{[1
,3
]}

Trevis, Sophie ^{[21
]}

Pinon, Vincent ^{[21
]}

Pezet, Denis ^{[22
]}

Balayssac, David ^{[1
,2
]}

机构：

[1] Univ Clermont Auvergne, INSERM U1107 NEURO DOL, Clermont Ferrand, France

[2] CHU Clermont Ferrand, Delegat Rech Clin & Innovat, Clermont Ferrand, France

[3] Univ Clermont Auvergne, Inst Analgesia, Clermont Ferrand, France

[4] CHU Clermont Ferrand, Serv Oncol Digest, Clermont Ferrand, France

[5] Ctr Hosp St Flour, Serv Chirurg Gen & Viscerale, St Flour, France

[6] Ctr Hosp Moulins Yzeure, Serv Oncol, Moulins, France

[7] CHRU Lille, Serv Oncol, Lille, France

[8] Univ Reims, Serv Oncol Digest, CHU Reims, Reims, France

[9] Univ Reims, Serv Pharm, SFR CAP Sante, BioSpect,CHU Reims, Reims, France

[10] Ctr Hosp Boulogne Sur Mer, Serv Oncol Digest, Boulogne Sur Mer, France

[11] CHU Limoges, Serv Oncol, Limoges, France

[12] Univ Montpellier, INSERM, IRCM, ICM, Montpellier, France

[13] Infirmerie Protestante Lyon, Serv Gastroenterol, Caluire Et Cuire, France

[14] Ctr Hosp Emile Roux, Serv Oncol, Le Puy En Velay, France

[15] Ctr Hosp Beziers, Serv Gastroenterol, Beziers, France

[16] Ctr Hosp St Joseph St Luc, Serv Hepatogastroenterol, Lyon, France

[17] Ctr Hosp Alpes Leman, Serv Gastro Enterol, Contamine Sur Arve, France

[18] Ctr Hosp Intercommunal Hop Leman, Serv Gastroenterol, Thonon Les Bains, France

[19] Ctr Hosp Vichy, Serv Chirurg Digest & Viscerale, Vichy, France

[20] Grp Hosp Mutualiste Grenoble, Serv Oncol, Grenoble, France

[21] CHU Clermont Ferrand, Serv Pharm, Clermont Ferrand, France

[22] Univ Clermont Auvergne, CHU Clermont Ferrand, USC INRA 2018, INSERM,M2iSH, Clermont Ferrand, France

来源：

FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷

关键词：

chemotherapy-induced peripheral neuropathy; neuropathic pain; colorectal cancer; oxaliplatin; cluster analysis; NEUROTOXICITY; QUESTIONNAIRE; PREVENTION; GUIDELINES; RISK;

D O I：

10.3389/fphar.2021.744085

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oxaliplatin, a pivotal drug in the management of colorectal cancer, causes chemotherapy-induced peripheral neuropathy (CIPN) in a third of cancer survivors. Based on a previous cross-sectional study assessing oxaliplatin-related sensory CIPN in colorectal cancer survivors, a secondary analysis was designed to explore the possibility that different clusters of patients may co-exist among a cohort of patients with oxaliplatin-related CIPN. Other objectives were to characterize these clusters considering CIPN severity, anxiety, depression, health-related quality of life (HRQOL), patients' characteristics and oxaliplatin treatments. Among the 96 patients analyzed, three clusters were identified (cluster 1: 52, cluster 2: 34, and cluster 3: 10 patients). Clusters were significantly different according to CIPN severity and the proportion of neuropathic pain (cluster 1: low, cluster 2: intermediate, and cluster 3: high). Anxiety, depressive disorders and HRQOL alteration were lower in cluster 1 in comparison to clusters 2 and 3, but not different between clusters 2 and 3. This study underlines that patients with CIPN are not a homogenous group, and that CIPN severity is associated with psychological distress and a decline of HRQOL. Further studies are needed to explore the relation between clusters and CIPN management.

引用

页数：10

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