Genetic regulation of Mycobacterium tuberculosis in a lipid-rich environment

被引：8
|
作者：
Aguilar-Ayala, Diana A. [1 ,2 ]
Palomino, Juan Carlos [2 ]
Vandamme, Peter [2 ]
Martin, Anandi [2 ]
Gonzalez-y-Merchand, Jorge A. [1 ,3 ]
机构：
[1] Inst Politecn Nacl, Dept Microbiol, Escuela Nacl Ciencias Biol, Prolongac Carpio & Plan Ayala S-N, Mexico City, DF, Mexico
[2] Univ Ghent, Dept Biochem & Microbiol, Fac Sci, KL Ledeganckstr 35, Ghent, Belgium
[3] Red Multidisciplinaria Invest TB, Mexico City, DF, Mexico
来源：
INFECTION GENETICS AND EVOLUTION | 2017年 / 55卷
关键词：
M. tuberculosis gene expression; M. tuberculosis microenvironments; M. tuberculosis lipids; M. tuberculosis stress responses; M; tuberculosis; TRANSCRIPTIONAL ADAPTATION; CHOLESTEROL UTILIZATION; PH; CATABOLISM; VIRULENCE; COMPLEX; GROWTH; MODEL; KSTR; IDENTIFICATION;
D O I：
10.1016/j.meegid.2016.10.015
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Tuberculosis (TB) remains as one of the leading causes of morbidity and mortality among infectious diseases worldwide. Although lipids (mainly fatty acids and cholesterol) have been reported to play an important role during active and latent infection of M. tuberculosis, there are other molecular aspects of bacterial response to those substrates that are not fully understood, involving gene regulation background. This review highlights recent insights on pathogen gene expression: regulation during its active growth, during survival in presence of lipids and under variable hostile host microenvironments. We also propose several application options of this knowledge that may contribute for improved TB control. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：392 / 402
页数：11
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