Platelet CD40L at the interface of adaptive immunity

被引：61

作者：

Elzey, Bennett D. ^{[1
,2
]}

Ratliff, Timothy L. ^{[2
,3
]}

Sowa, Jennifer M. ^{[2
]}

Crist, Scott A. ^{[2
]}

机构：

[1] Indiana Univ Sch Med, Dept Urol, IUPUI, Indianapolis, IN 46202 USA

[2] Purdue Univ, Dept Comparat Pathobiol, W Lafayette, IN 47907 USA

[3] Purdue Univ, Purdue Univ Ctr Canc Res, W Lafayette, IN 47907 USA

来源：

THROMBOSIS RESEARCH | 2011年 / 127卷 / 03期

关键词：

T lymphocyte; B lymphocyte; Platelet; CD40L; Immunity; Inflammation; INFLAMMATORY-BOWEL-DISEASE; ACTIVATED PLATELETS; MEDIATED MODULATION; DENDRITIC CELLS; T-CELLS; LIGAND; MECHANISM; CD154; NEUTROPHILS; THROMBOSIS;

D O I：

10.1016/j.thromres.2010.10.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Initiated by the finding that platelets express functional CD40 ligand (CD40L, CD154), many new roles for platelets have been discovered in unanticipated areas, including the immune response. When current literature is considered as a whole, the picture that is emerging begins to show that platelets are able to significantly affect, for better or worse, the overall health and condition of the mammalian host. Animal models have made significant contributions to our expanding knowledge of platelet function, much of which is anticipated to be clinically relevant. While still mostly circumstantial, the evidence supports a critical role for CD40L in many normal and disease processes. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：180 / 183

页数：4

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