Transcription factors and translocations in lymphoid and myeloid leukemia

被引：42
作者：
Crans, HN
Sakamoto, KM
机构：
[1] Univ Calif Los Angeles, Sch Med, Dept Pediat, Div Hematol Oncol, Los Angeles, CA 90024 USA
[2] Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Div Hematol Oncol, Los Angeles, CA 90024 USA
[3] Jonsson Comprehens Canc Ctr, Los Angeles, CA 90034 USA
来源：
LEUKEMIA | 2001年 / 15卷 / 03期
关键词：
transcription factor; translocation; leukemia;
D O I：
10.1038/sj.leu.2402033
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chromosomal translocations involving transcription factors and aberrant expression of transcription factors are frequently associated with leukemogenesis. Transcription factors are essential in maintaining the regulation of cell growth, development, and differentiation in the hematopoietic system. Alterations in the mechanisms that normally control these functions can lead to hematological malignancies. Further characterization of the molecular biology of leukemia will enhance our ability to develop disease-specific treatment strategies, and to develop effective methods of diagnosis and prognosis.
引用
收藏
页码：313 / 331
页数：19
相关论文
共 325 条
[1]   Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PML [J].
Ahn, JH ;
Brignole, EJ ;
Hayward, GS .
MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (08) :4899-4913
[2]   Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO(MTG8) [J].
Ahn, MY ;
Huang, G ;
Bae, SC ;
Wee, HJ ;
Kim, WY ;
Ito, Y .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (04) :1812-1817
[3]  
Alberts B, 1989, MOL BIOL CELL
[4]   ACTIVATION OF CAMP AND MITOGEN RESPONSIVE GENES RELIES ON A COMMON NUCLEAR FACTOR [J].
ARIAS, J ;
ALBERTS, AS ;
BRINDLE, P ;
CLARET, FX ;
SMEAL, T ;
KARIN, M ;
FERAMISCO, J ;
MONTMINY, M .
NATURE, 1994, 370 (6486) :226-229
[5]   Functional and regulatory interactions between Hox and extradenticle genes [J].
Azpiazu, N ;
Morata, G .
GENES & DEVELOPMENT, 1998, 12 (02) :261-273
[6]   DOMINANT INTERFERING ALLELES DEFINE A ROLE FOR C-MYB IN T-CELL DEVELOPMENT [J].
BADIANI, P ;
CORBELLA, P ;
KIOUSSIS, D ;
MARVEL, J ;
WESTON, K .
GENES & DEVELOPMENT, 1994, 8 (07) :770-782
[7]  
BAE SC, 1993, ONCOGENE, V8, P809
[8]   THE HUMAN C-MYC-ONCOGENE - STRUCTURAL CONSEQUENCES OF TRANSLOCATION INTO THE IGH LOCUS IN BURKITT-LYMPHOMA [J].
BATTEY, J ;
MOULDING, C ;
TAUB, R ;
MURPHY, W ;
STEWART, T ;
POTTER, H ;
LENOIR, G ;
LEDER, P .
CELL, 1983, 34 (03) :779-787
[9]   CHROMOSOMAL TRANSLOCATION IN A HUMAN-LEUKEMIC STEM-CELL LINE DISRUPTS THE T-CELL ANTIGEN RECEPTOR DELTA-CHAIN DIVERSITY REGION AND RESULTS IN A PREVIOUSLY UNREPORTED FUSION TRANSCRIPT [J].
BEGLEY, CG ;
APLAN, PD ;
DAVEY, MP ;
NAKAHARA, K ;
TCHORZ, K ;
KURTZBERG, J ;
HERSHFIELD, MS ;
HAYNES, BF ;
COHEN, DI ;
WALDMANN, TA ;
KIRSCH, IR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (06) :2031-2035
[10]  
BEN-DAVID Y, 1990, New Biologist, V2, P1015
12345678910