Drug encapsulation within self-assembled microglobules formed by thermoresponsive supramolecules

被引：21
|
作者：
Betancourt, Jose E. [1 ]
Subramani, Chandramouleeswaran [2 ]
Serrano-Velez, Jose L. [3 ]
Rosa-Molinar, Eduardo [3 ]
Rotello, Vincent M. [2 ]
Rivera, Jose M. [1 ]
机构：
[1] Univ Puerto Rico, Dept Chem, San Juan, PR 00931 USA
[2] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA
[3] Univ Puerto Rico, Dept Biol, San Juan, PR 00931 USA
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 45期
基金：
美国国家科学基金会;
关键词：
PH-RESPONSIVE MICELLES; 2'-DEOXYGUANOSINE DERIVATIVES; DELIVERY; NANOCARRIERS; DOXORUBICIN; POLYMERS; COMPLEX;
D O I：
10.1039/c0cc04063k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An 8-(phenyl)-2'-deoxyguanosine derivative self-assembles in aqueous media into discrete hexadecamers that further self-assemble above 32 degrees C into microglobules that encapsulate the drug doxorubicin.
引用
收藏
页码：8537 / 8539
页数：3
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