Drug encapsulation within self-assembled microglobules formed by thermoresponsive supramolecules

被引：21

作者：

Betancourt, Jose E. ^{[1
]}

Subramani, Chandramouleeswaran ^{[2
]}

Serrano-Velez, Jose L. ^{[3
]}

Rosa-Molinar, Eduardo ^{[3
]}

Rotello, Vincent M. ^{[2
]}

Rivera, Jose M. ^{[1
]}

机构：

[1] Univ Puerto Rico, Dept Chem, San Juan, PR 00931 USA

[2] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

[3] Univ Puerto Rico, Dept Biol, San Juan, PR 00931 USA

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 45期

基金：

美国国家科学基金会;

关键词：

PH-RESPONSIVE MICELLES; 2'-DEOXYGUANOSINE DERIVATIVES; DELIVERY; NANOCARRIERS; DOXORUBICIN; POLYMERS; COMPLEX;

D O I：

10.1039/c0cc04063k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An 8-(phenyl)-2'-deoxyguanosine derivative self-assembles in aqueous media into discrete hexadecamers that further self-assemble above 32 degrees C into microglobules that encapsulate the drug doxorubicin.

引用

页码：8537 / 8539

页数：3

共 20 条

[1] Hexadecameric self-assembled dendrimers built from 2′-deoxyguanosine derivatives
Betancourt, Jose E.
Rivera, Jose M.
[J]. ORGANIC LETTERS, 2008, 10 (11) : 2287 - 2290
[2] Nonpolymeric Thermosensitive Supramolecules
Betancourt, Jose E.
Rivera, Jose M.
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (46) : 16666 - +
[3] Solvent-Induced High Fidelity Switching Between Two Discrete Supramolecules
Betancourt, Jose E.
Martin-Hidalgo, Mariana
Gubala, Vladimir
Rivera, Jose M.
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (09) : 3186 - +
[4] Targeted drug delivery by thermally responsive polymers
Chilkoti, A
Dreher, MR
Meyer, DE
Raucher, D
[J]. ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (05) : 613 - 630
[5] Structure of the first parallel DNA quadruplex-drug complex
Clark, GR
Pytel, PD
Squire, CJ
Neidle, S
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (14) : 4066 - 4067
[6] Isostructural self-assembly of 2′-deoxyguanosine derivatives in aqueous and organic media
Garcia-Arriaga, Marilyn
Hobley, Gerard
Rivera, Jose M.
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (32) : 10492 - +
[7] Applying biological principles to the assembly and selection of synthetic superstructures
Greig, LM
Philp, D
[J]. CHEMICAL SOCIETY REVIEWS, 2001, 30 (05) : 287 - 302
[8] A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas
Lee, Cameron C.
Gillies, Elizabeth R.
Fox, Megan E.
Guillaudeu, Steven J.
Frechet, Jean M. J.
Dy, Edward E.
Szoka, Francis C.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (45) : 16649 - 16654
[9] Toward self-organization and complex matter
Lehn, JM
[J]. SCIENCE, 2002, 295 (5564) : 2400 - 2403
[10] Incorporation and in vitro release of doxorubicin in thermally sensitive micelles made from poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-poly(D,L-lactide-co-glycolide) with varying compositions
Liu, SQ
Tong, YW
Yang, YY
[J]. BIOMATERIALS, 2005, 26 (24) : 5064 - 5074

← 1 2 →