Two new C21 steroidal glycosides isolated from Cynanchum komarovii

被引：8

作者：

Zhao Dan ^{[1
,2
]}

Su Shan-Shan ^{[3
]}

Chen Shao-Fei ^{[1
,2
]}

Lu Xiao-Jie ^{[1
,2
]}

Chen Gang ^{[1
,2
]}

Wang Yu-Bo ^{[1
,2
,4
]}

Su Guang-Yue ^{[1
,2
]}

Pei Yue-Hu ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Liaoning, Peoples R China

[3] Qinghai Entry Exit Inspect & Quarantine Bur, Testing Lab, Xining 810000, Qinghai, Peoples R China

[4] Jinzhou Med Univ, Sch Pharm, Jinzhou 121001, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2018年 / 16卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Cynanchum komarovii; C-21 steroidal glycosides; Cytotoxic activity; GLAUCESCENS HAND-MAZZ; DRUG PAI-CHIEN; ASCLEPIADACEAE PLANTS; CONSTITUENTS; ROOTS; PANICULATUM; ATRATUM;

D O I：

10.1016/S1875-5364(18)30098-0

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The present study was designed to further investigate the C-21 steroidal glycosides in Cynanchum plants. Two new steroidal glycosides based on a 13, 14:14, 15-disecopregnane-type aglycone, komaroside P (1) and komaroside Q (2), together with three known compounds (3-5) were isolated from the whole herbs of Cynanchum komarovii. The aglycones of compounds 1 and 2 were two new disecopregnane. Their structures were elucidated on the basis of 1D, 2D NMR spectroscopic data and acid hydrolysis. All the compounds (1-5) showed potent inhibitory activities against human leukemia cell lines (HL-60) with IC50 values ranging from 16.6 to 26.3 mu mol.L-1, compared to the positive control 5-fluorouracil (6.4 mu mol.L-1).

引用

页码：610 / 614

页数：5

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