Stimulation by nerve growth factor of neuropeptide synthesis in the adult rat in vivo: Bilateral response to unilateral intraplantar injections

被引：75

作者：

Amann, R ^{[1
]}

Sirinathsinghji, DJS ^{[1
]}

Donnerer, J ^{[1
]}

Liebmann, I ^{[1
]}

Schuligoi, R ^{[1
]}

机构：

[1] MERCK SHARP & DOHME RES LABS,CTR RES NEUROSCI,HARLOW CM20 2QR,ESSEX,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1996年 / 203卷 / 03期

关键词：

dorsal root ganglion; in situ hybridization histochemistry; nerve growth factor; neuropeptides; rat;

D O I：

10.1016/0304-3940(95)12287-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Unilateral intraplantar injections (1/day for 3 days) of 4 mu g nerve growth factor (NGF) into the rat hindpaw increased the expression of prepro-tachykinin (PPT)- and prepro-calcitonin gene-related peptide (ppCGRP)-mRNA in bilateral L(5) dorsal root ganglia (DRGs). This was accompanied by an increase of CGRP-like immunoreactivity in the ipsi- and contralateral sciatic nerve but by no detectable change of CGRP-IR in other afferents. NGF injections into the skin of one ear or into the plantar side of one forepaw increased CGRP-IR in the respective afferents (trigeminal ganglion, or nerves arising from the brachial plexus, respectively), but had no effect on sciatic CGRP-IR. This suggests that the NGF-induced symmetrical increase of CGRP synthesis in L(5) DRGs was not caused by systemic action of NGF, which, therefore, may be a useful tool to further investigate mechanisms which are responsible for contralateral effects of unilateral inflammation.

引用

页码：171 / 174

页数：4

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