[2+3] Annulative Coupling of Tetrahydroisoquinolines with Aryliodonio diazo compounds To Access 1,2,4-Triazolo[3,4-a]isoquinolines

被引：11

作者：

Ansari, Monish Arbaz ^{[1
]}

Khan, Shahnawaz ^{[1
]}

Ray, Subhasish ^{[1
]}

Shukla, Gaurav ^{[1
]}

Singh, Maya Shankar ^{[1
]}

机构：

[1] Banaras Hindu Univ, Inst Sci, Dept Chem, Varanasi 221005, India

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 32期

关键词：

CATALYZED OXY-ALKYNYLATION; H BOND FUNCTIONALIZATION; SILYL ENOL ETHERS; HYPERVALENT IODINE(III); CONCISE SYNTHESIS; CHEMISTRY; ISOQUINOLINE; DERIVATIVES; ALKALOIDS; ARYLATION;

D O I：

10.1021/acs.orglett.2c02442

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Base promoted one-pot annulative coupling of 1,2,3,4-tetrahydroisoquinolines (THIQs) with hypervalent iodine(III) species aryliodonio diazo compounds has been devised for the direct construction of 1,2,4-triazolo[3,4-a]isoquinoline derivatives at room temperature in open air for the first time. This approach involves [2 + 3] cascade annulation of nucleophilic THIQ with an electrophilic aryliodonio diazo compound via N-H and alpha-C1(sp3)-H difunction-alization of THIQ.

引用

收藏

页码：6078 / 6082

页数：5

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