Anticoagulant effects of a Cannabis extract in an obese rat model

被引：38

作者：

Coetzee, C. ^{[1
]}

Levendal, R.-A. ^{[1
]}

van de Venter, M. ^{[1
]}

Frost, C. L. ^{[1
]}

机构：

[1] Nelson Mandela Metropolitan Univ, Dept Biochem & Microbiol, ZA-6031 Port Elizabeth, South Africa

来源：

PHYTOMEDICINE | 2007年 / 14卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

cannabis; blood coagulation; obesity; anticoagulant; cannabinoids;

D O I：

10.1016/j.phymed.2006.02.004

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Blood coagulation studies were conducted to determine the possible anti-/prothrombotic effect of an organic cannabis extract and the three major cannabinoids, THC, CBD and CBN. The in vitro effect of the cannabis extract on thrombin activity produced an IC50 value of 9.89 mg/ml, compared to THC at 1.79 mg/ml. It was also found that the extract, THC and CBN showed considerable inhibition of thrombin-induced clot formation in vitro with IC50 values of 600, 87 and 83 mu g/ml for the extract, THC and CBN respectively. In an in vivo model used to determine clotting times of lean and obese rats treated with a cannabis extract, 50% clotting times were found to be 1.5 and 2 fold greater than their respective control groups, supporting the results obtained in the in vitro model. The study thus shows that Cannabis sativa and the cannabinoids, THC and CBN, display anticoagulant activity and may be useful in the treatment of diseases such as type 2 diabetes in which a hypercoagulable state exists. (C) 2006 Elsevier GmbH. All rights reserved.

引用

页码：333 / 337

页数：5

共 21 条

[1] Pharmacology and effects of cannabis: a brief review [J].