Reaction of methylcerium reagent with tertiary amides: Synthesis of saturated and unsaturated ketones from tertiary amides

被引：37

作者：

Kurosu, M ^{[1
]}

Kishi, Y ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 27期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(98)00959-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of CeCl3 . MeLi to tertiary amides has been studied. The reagent prepared from cerium(III) chloride and methyllithium at 0 degrees C adds cleanly to morpholine amides to give the corresponding methyl ketones. Even in the presence of a large excess of the reagent, no tertiary alcohol formation is observed, indicating that the tetrahedral intermediates are stable under the reaction conditions employed. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4793 / 4796

页数：4

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