Using epigenetic modifiers to target cancer stem cell immunoevasion

被引：8
|
作者：
Galassi, Claudia [1 ]
Vitale, Ilio [2 ,3 ]
Galluzzi, Lorenzo [1 ,4 ,5 ]
机构：
[1] Weill Cornell Med Coll, Dept Radiat Oncol, New York, NY 10065 USA
[2] IRCSS Candiolo, Italian Inst Genom Med, Turin, Italy
[3] FPO IRCCS, Candiolo Canc Inst, Candiolo, Italy
[4] Sandra & Edward Meyer Canc Ctr, New York, NY 10065 USA
[5] Caryl & Israel Englander Inst Precis Med, New York, NY 10065 USA
来源：
CANCER CELL | 2021年 / 39卷 / 12期
关键词：
endogenous retroviruses; immune checkpoint inhibitors; KDM5B; MAVS; STING1; type I IFN;
D O I：
10.1016/j.ccell.2021.11.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Two recent reports in Nature highlight a novel mechanism of immunoevasion that relies on the SET domain bifurcated histone lysine methyltransferase 1 (SETDB1)-dependent epigenetic suppression of endogenous retroelements in melanoma cells. Because SETDB1 is highly expressed by the stem cell compartment, these findings delineate an innovative strategy for restoring cancer stem cell immunosurveillance.
引用
收藏
页码：1573 / 1575
页数：3
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