The microbiota is important for IL-17A expression and neutrophil infiltration in lesional skin of Flgft/ft mice

被引：14

作者：

Hoff, Sabine ^{[1
]}

Oyoshi, Michiko K. ^{[1
]}

Macpherson, Andrew ^{[2
]}

Geha, Raif S. ^{[1
]}

机构：

[1] Boston Childrens Hosp, Div Immunol, Boston, MA USA

[2] Univ Bern, Div Gastroenterol & Mucosal Immunol, Bern, Switzerland

来源：

CLINICAL IMMUNOLOGY | 2015年 / 156卷 / 02期

关键词：

Atopic dermatitis; Microbiota; Filaggrin-deficiency; Skin inflammation; T(H)17; ATOPIC-DERMATITIS; FILAGGRIN; GENE;

D O I：

10.1016/j.clim.2014.12.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

引用

页码：128 / 130

页数：3

共 10 条

[1] Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood [J].

Barker, Jonathan N. W. N. ;

Palmer, Colin N. A. ;

Zhao, Yiwei ;

Liao, Haihui ;

Hull, Peter R. ;

Lee, Simon P. ;

Allen, Michael H. ;

Meggitt, Simon J. ;

Reynolds, Nicholas J. ;

Trembath, Richard C. ;

McLean, W. H. Irwin .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 (03) :564-567

[2] A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming [J].

Fallon, Padraic G. ;

Sasaki, Takashi ;

Sandilands, Aileen ;

Campbell, Linda E. ;

Saunders, Sean P. ;

Mangan, Niamh E. ;

Callanan, John J. ;

Kawasaki, Hiroshi ;

Shiohama, Aiko ;

Kubo, Akiharu ;

Sundberg, John P. ;

Presland, Richard B. ;

Fleckman, Philip ;

Shimizu, Nobuyoshi ;

Kudoh, Jun ;

Irvine, Alan D. ;

Amagai, Masayuki ;

McLean, W. H. Irwin .

NATURE GENETICS, 2009, 41 (05) :602-608

[3] Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice [J].

Kawasaki, Hiroshi ;

Nagao, Keisuke ;

Kubo, Akiharu ;

Hata, Tsuyoshi ;

Shimizu, Atsushi ;

Mizuno, Hideaki ;

Yamada, Taketo ;

Amagai, Masayuki .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 129 (06) :1538-+

[4] Toll-Like Receptors Link Atopic March to the Hygiene Hypothesis [J].

Kemeny, Lajos ;

Szabo, Kornelia .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2013, 133 (04) :874-878

[5] Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis [J].

Kong, Heidi H. ;

Oh, Julia ;

Deming, Clay ;

Conlan, Sean ;

Grice, Elizabeth A. ;

Beatson, Melony A. ;

Nomicos, Effie ;

Polley, Eric C. ;

Komarow, Hirsh D. ;

Murray, Patrick R. ;

Turner, Maria L. ;

Segre, Julia A. .

GENOME RESEARCH, 2012, 22 (05) :850-859

[6] Development of skin lesions in filaggrin-deficient mice is dependent on adaptive immunity [J].

Leisten, Sabine ;

Oyoshi, Michiko K. ;

Galand, Claire ;

Hornick, Jason L. ;

Gurish, Michael F. ;

Geha, Raif S. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 131 (04) :1247-+

[7] Interleukin-17 Drives Pulmonary Eosinophilia following Repeated Exposure to Aspergillus fumigatus Conidia [J].

Murdock, Benjamin J. ;

Falkowski, Nicole R. ;

Shreiner, Andrew B. ;

Akha, Amir A. Sadighi ;

McDonald, Roderick A. ;

White, Eric S. ;

Toews, Galen B. ;

Huffnagle, Gary B. .

INFECTION AND IMMUNITY, 2012, 80 (04) :1424-1436

[8] Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen [J].

Oyoshi, Michiko K. ;

Murphy, George F. ;

Geha, Raif S. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 124 (03) :485-U145

[9] Loss of normal profilaggrin and filaggrin in flaky tail (ft/ft) mice:: an animal model for the filaggrin-deficient skin disease ichthyosis vulgaris [J].

Presland, RB ;

Boggess, D ;

Lewis, SP ;

Hull, C ;

Fleckman, P ;

Sundberg, JP .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2000, 115 (06) :1072-1081

[10] Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects [J].

Saunders, Sean P. ;

Goh, Christabelle S. M. ;

Brown, Sara J. ;

Palmer, Colin N. A. ;

Porter, Rebecca M. ;

Cole, Christian ;

Campbell, Linda E. ;

Gierlinski, Marek ;

Barton, Geoffrey J. ;

Schneider, Georg ;

Balmain, Allan ;

Prescott, Alan R. ;

Weidinger, Stephan ;

Baurecht, Hansjoerg ;

Kabesch, Michael ;

Gieger, Christian ;

Lee, Young-Ae ;

Tavendale, Roger ;

Mukhopadhyay, Somnath ;

Turner, Stephen W. ;

Madhok, Vishnu B. ;

Sullivan, Frank M. ;

Relton, Caroline ;

Burn, John ;

Meggitt, Simon ;

Smith, Catherine H. ;

Allen, Michael A. ;

Barker, Jonathan N. W. N. ;

Reynolds, Nick J. ;

Cordell, Heather J. ;

Irvine, Alan D. ;

McLean, W. H. Irwin ;

Sandilands, Aileen ;

Fallon, Padraic G. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 132 (05) :1121-1129

← 1 →