Water-soluble Bis(thiosemicarbazonato)copper(II) Complexes

被引：13
|
作者：
Buncic, Gojko [1 ,2 ]
Hickey, James L. [1 ,2 ]
Schieber, Christine [1 ,2 ]
White, Jonathan M. [1 ,2 ]
Crouch, Peter J. [3 ,4 ]
White, Anthony R. [3 ,4 ]
Xiao, Zhiguang [1 ,2 ]
Wedd, Anthony G. [1 ,2 ]
Donnelly, Paul S. [1 ,2 ]
机构：
[1] Univ Melbourne, Sch Chem, Melbourne, Vic 3010, Australia
[2] Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Melbourne, Vic 3010, Australia
[3] Univ Melbourne, Ctr Neurosci, Melbourne, Vic 3010, Australia
[4] Univ Melbourne, Dept Pathol, Melbourne, Vic 3010, Australia
来源：
AUSTRALIAN JOURNAL OF CHEMISTRY | 2011年 / 64卷 / 03期
基金：
澳大利亚研究理事会; 英国医学研究理事会;
关键词：
COPPER RADIOPHARMACEUTICALS; BIFUNCTIONAL CHELATORS; MECHANISM; LIGANDS; AGENT; SELECTIVITY; CU-64-ATSM; VERSATILE; BINDING; ZINC;
D O I：
10.1071/CH10463
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis of four new water-soluble bis(thiosemicarbazone) ligands and their copper(II) complexes is presented and their potential to be new ligands for copper radiopharmaceuticals is discussed. The ligands and complexes have been characterized by a combination of NMR spectroscopy, mass spectrometry, and X-ray crystallography. The electrochemical behaviour of two of the copper(II) complexes was investigated by cyclic voltammetry and revealed that both complexes exhibited a quasi-reversible redox process attributed to a Cu-II/Cu-I process. Two of the new ligands were radiolabelled with positron-emitting Cu-64 with a view to assessing their potential as ligands that bind radioactive copper isotopes for application in diagnostic radiopharmaceuticals. The cellular uptake of the copper complexes was investigated in SH-SY5Y cells.
引用
收藏
页码：244 / 252
页数：9
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