Increased risk of pyogenic liver abscess in patients with alcohol intoxication: A population-based retrospective cohort study

被引：9
作者：
Wang, Yao-Chien [1 ,2 ]
Yang, Kai-Wei [1 ,2 ]
Lee, Tien-Ying Peter [3 ]
Lin, Cheng-Li [4 ]
Liaw, Geng-Wang [1 ,2 ]
Hung, Dong-Zong [2 ,5 ]
Kao, Chia-Hung [2 ,6 ,7 ,8 ,9 ]
Chen, Wei-Kung [1 ,2 ]
Yang, Tse-Yen [10 ,11 ]
机构：
[1] China Med Univ Hosp, Dept Emergency Med, Taichung, Taiwan
[2] China Med Univ, Sch Med, Coll Med, Taichung, Taiwan
[3] YeeZen Gen Hosp, Taoyuan, Taiwan
[4] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan
[5] China Med Univ Hosp, Dept Toxicol, Taichung, Taiwan
[6] China Med Univ, Coll Med, Grad Inst Clin Med Sci, Taichung, Taiwan
[7] China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan
[8] China Med Univ Hosp, PET Ctr, Taichung, Taiwan
[9] Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan
[10] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung, Taiwan
[11] China Med Univ, Dept Med Lab Sci & Biotechnol, Taichung, Taiwan
来源：
ALCOHOL | 2017年 / 64卷
关键词：
Alcohol intoxication; Pyogenic liver abscess; National health insurance research database; Population-based cohort; NATIONWIDE-COHORT; CONSUMPTION; ETHANOL; INFLAMMATION; DISEASE; IMPAIRS; PROTEIN;
D O I：
10.1016/j.alcohol.2017.05.003
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
We designed a population-based retrospective cohort study to investigate the association between the event of alcohol intoxication and the risk of pyogenic liver abscess. The present study enrolled 245,076 patients with a history of alcohol intoxication from 2000 to 2010 and matched each of them with four comparison patients, with similar mean age and sex ratios. We determined the cumulative incidences and adjusted hazard ratios (aHRs) of liver abscess. A significant association was observed between alcohol intoxication and liver abscess. The incidence density rate of liver abscess was 3.47-fold greater in the alcohol intoxication (AI) cohort than in the non-AI cohort (12.2 vs. 3.43 per 10,000 person-years), with an adjusted HR (aHR) of 2.64 (95% CI = 2.26 to 3.08). This population-based study positively associated the event of alcohol intoxication with increased risk of liver abscess. Our findings warrant further large-scale and in-depth investigations in this area. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：23 / 28
页数：6
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