Relation of CD39 to plaque instability and thrombus formation in directional atherectomy specimens from patients with stable and unstable angina pectoris

被引：14
作者：
Hatakeyama, K
Hao, H
Imamura, T
Ishikawa, T
Shibata, Y
Fujimura, Y
Eto, T
Asada, Y
机构：
[1] Miyazaki Univ, Miyazaki Med Coll, Dept Pathol 1, Miyazaki 8891692, Japan
[2] Miyazaki Univ, Miyazaki Med Coll, Dept Internal Med 1, Miyazaki 8891692, Japan
[3] Miyazaki Med Assoc Hosp, Miyazaki, Japan
[4] Natl Cardiovasc Ctr, Dept Pathol, Suita, Osaka 565, Japan
[5] Nara Med Univ, Dept Blood Transfus Med, Nara, Japan
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 2005年 / 95卷 / 05期
关键词：
D O I：
10.1016/j.amjcard.2004.11.012
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
To determine whether the expression of CD39 in coronary atherosclerotic lesions is related to plaque instability and thrombus formation, we assessed directional coronary atherectomy (DCA) specimens from patients with stable and unstable angina pectoris. CD39 immunoreactivity was decreased in culprit lesions in patients with unstable angina pectoris compared with those with stable angina pectoris, and was reduced in DCA specimens with thrombus formation. These results suggest that CD39 expressed in atheromatous plaque plays an important role in preventing acute coronary syndromes. (C)2005 by Excerpta Medical Inc.
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页码：632 / 635
页数：4
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