In Vitro Susceptibility of Fusarium to Isavuconazole

被引：14
作者：
Broutin, A. [1 ]
Bigot, J. [2 ]
Senghor, Y. [1 ]
Moreno-Sabater, A. [1 ,3 ]
Guitard, J. [2 ]
Hennequin, C. [2 ]
机构：
[1] Hop St Antoine, AP HP, Serv Parasitol Mycol, Paris, France
[2] Sorbonne Univ, Hop St Antoine, AP HP, INSERM,CRSA, Paris, France
[3] Sorbonne Univ, Ctr Immunol & Malad Infect CIMI Paris, INSERM U1135, Paris, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2020年 / 64卷 / 02期
关键词：
EUCAST; Fusarium; antifungal susceptibility testing; gradient concentration strip; isavuconazole; DESORPTION IONIZATION-TIME; FLIGHT MASS-SPECTROMETRY; ANTIFUNGAL SUSCEPTIBILITY; BROTH MICRODILUTION; IDENTIFICATION; ASPERGILLUS; INFECTIONS; COMPLEX; SPP; VORICONAZOLE;
D O I：
10.1128/AAC.01621-19
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
To evaluate the in vitro susceptibility of Fusarium to isavuconazole, 75 clinical isolates were identified using matrix-assisted laser desorption ionization-time of flight mass spectrometry and then tested with a broth microdilution method (EUCAST) and the gradient concentration strip (GCS) technique. The activity of isavuconazole overall was shown to be limited, with an MIC50 of >16 mu g/ml, without significant differences between the species complexes. The categorical agreement between GCS and EUCAST was 97.4% to 100%, making the GCS as a valuable alternative.
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页数：5
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