Anti-inflammatory property of the urinary metabolites of nobiletin in mouse

被引：165
作者：
Li, Shiming
Sang, Shengmin
Pan, Min-Hsiung
Lai, Ching-Shu
Lo, Chih-Yu
Yang, Chung S.
Ho, Chi-Tang
机构：
[1] Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA
[2] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Piscataway, NJ 08854 USA
[3] Natl Kaohsiung Marine Univ, Dept Seafood Sci, Kaohsiung, Taiwan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 18期
关键词：
nobiletin; nobiletin metabolites; demethylnobiletin; 3'; 4'-didemethylnobiletin; anti-inflammatory activity;
D O I：
10.1016/j.bmcl.2007.06.096
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Nobiletin, a major component of polymethoxyflavones in citrus fruits, has a broad spectrum of health beneficial properties including anti-inflammatory and anti-carcinogenic activities. The metabolite identification of nobiletin in mouse urine has concluded that it undergoes mono-demethylation (3 '- and 4 '-deinethylnobiletin) and di-demethylation (3 ',4 '-didemethylnobiletin) metabolic pathway. Biological screening of nobiletin and its metabolites has revealed that the metabolites possess more potent anti-inflammatory activity than their parent compound. Therefore, this letter reports the identification of nobiletin metabolites and their anti-inflammatory activity against LPS-induced NO production and iNOS, COX-2 protein expression in RAW264.7 macrophage. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5177 / 5181
页数：5
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