Domain Recombination: A Workhorse for Evolutionary Innovation

被引：33

作者：

Apic, Gordana ^{[1
,2
]}

Russell, Robert B. ^{[1
]}

机构：

[1] Heidelberg Univ, Cell Networks, D-69120 Heidelberg, Germany

[2] St Johns Innovat Ctr, Cambridge Cell Networks, Cambridge CB4 OWS, England

来源：

SCIENCE SIGNALING | 2010年 / 3卷 / 139期

关键词：

PROTEIN DOMAINS; ARCHITECTURES; NETWORKS; MODULES;

D O I：

10.1126/scisignal.3139pe30

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although the combination of modular domains within proteins has been proposed as a determining feature of evolutionary innovation and flexibility, direct evidence for this mechanism of evolution has been sketchy. Two papers, one creating new domain combinations in the yeast mating pathway and another involving a comprehensive analysis of protein function and domain architecture across major organisms, have provided firm evidence that the recombining of domains can lead to evolutionary innovation. The results will guide future studies in synthetic and evolutionary biology.

引用

页数：2

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