Effects of platelet-rich plasma on intestinal wound healing in pigs

被引：40

作者：

Fresno, Laura ^{[1
]}

Fondevila, Dolors ^{[1
]}

Bambo, Otilia ^{[1
]}

Chacaltana, Asiul ^{[1
]}

Garcia, Felix ^{[1
]}

Andaluz, Anna ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, E-08193 Barcelona, Spain

来源：

VETERINARY JOURNAL | 2010年 / 185卷 / 03期

关键词：

Intestine; Wound healing; Platelet-rich plasma; Breaking strength; Pig; BURSTING PRESSURE; ANASTOMOSES; STRENGTH; IMPROVES; PROLIFERATION; PARAMETERS;

D O I：

10.1016/j.tvjl.2009.06.009

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Anastomotic dehiscence and leakage remain a major problem in gastrointestinal surgery. Recently, attention has been focused on cellular acceleration of the wound healing process using platelet-rich plasma (PRP) and this study reports the effects of PRP on intestinal wound healing in pigs. Autologous PRP was obtained from 35 pigs that were then subjected to two intestinal anastomosis procedures. Activated PRP was applied at one of the anastomosis sites, while the other site served as control. After 24, 48, 72 and 96 h and then at 7 days, histology was performed and wound breaking strength was measured at 72 h and 7 days. PRP application appeared to increase granulation tissue and fibrosis, but did not influence anastomotic breaking strength. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：322 / 327

页数：6

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