More Radical Magic with B12: B12-Catalyzed, Light-Induced Cleavage of DNA

被引：7

作者：

Kraeutler, Bernhard ^{[1
,2
]}

Puffer, Barbara

机构：

[1] Univ Innsbruck, Inst Organ Chem, A-6020 Innsbruck, Austria

[2] Univ Innsbruck, Ctr Mol Biosci CMBI, A-6020 Innsbruck, Austria

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 42期

关键词：

bioinorganic chemistry; DNA cleavage; photo-chemistry; radical reactions; reactive oxygen species; vitamins; CHEMISTRY;

D O I：

10.1002/anie.201103373

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

B12 in a new light: The B12 derivative hydroxocobalamin can be used as an efficient catalyst for light-induced strand cleavage of DNA. The proposed radical process involves hydroxy radicals and is controlled by visible light (see scheme). Such light-controlled radical reactions promise to be particularly useful in intracellular applications. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9791 / 9792

页数：2

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