Intramolecular oxidative coupling: I2/TBHP/NaN3-mediated synthesis of benzofuran derivatives

被引：16

作者：

Xu, Wengang ^{[1
]}

Li, Qingcui ^{[1
]}

Cao, Chuanpeng ^{[1
]}

Zhang, Fanglin ^{[1
]}

Zheng, Hua ^{[1
]}

机构：

[1] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Hubei, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 22期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; BOND FORMATION; O-ARYLPHENOLS; IODINE; DIBENZOFURANS; CYCLIZATION; 2-ARYLBENZOFURANS; ACTIVATION; ANNULATION; INHIBITORS;

D O I：

10.1039/c5ob00577a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel intramolecular oxidative coupling reaction has been established to prepare benzofuran derivatives via direct C(sp(2))-H functionalization for the formation of C-O bond. This transformation is mediated by I-2/TBHP/NaN3 under metal-free conditions and a catalytic amount of NaN3 plays a crucial role in the reaction. Furthermore, the reaction tolerates a broad substrate scope with average to excellent yields.

引用

页码：6158 / 6161

页数：4

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