Facile Synthesis of Azaarene-Substituted 3-Hydroxy-2-oxindoles via Bronsted Acid Catalyzed sp3 C-H Functionalization

被引：142
|
作者：
Niu, Rui [1 ,2 ,3 ]
Xiao, Jian [1 ]
Liang, Tao [1 ]
Li, Xingwei [1 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
[2] Ocean Univ China, Coll Environm Sci & Engn, Qingdao 266100, Peoples R China
[3] Ocean Univ China, Minist Educ, Key Lab Marine Environm & Ecol, Qingdao 266100, Peoples R China
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 03期
基金：
中国国家自然科学基金;
关键词：
BAYLIS-HILLMAN REACTION; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC CATALYSIS; ISATIN DERIVATIVES; BOND ACTIVATION; 3-HYDROXYOXINDOLE DERIVATIVES; ARYLBORONIC ACIDS; ALPHA-KETOAMIDES; ALDOL REACTION; OXINDOLES;
D O I：
10.1021/ol2030982
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Bronsted acid catalyzed functionalization of sp(3) C-H bonds in 2-methyl azaarenes has been achieved in the reaction with isatins. This method provides facile synthesis of biologically important azaarene-substituted 3-hydroxy-2-oxindoles in one step in moderate to good yields.
引用
收藏
页码：676 / 679
页数：4
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