Regulation of tumor growth by IFN-γ in cancer immunotherapy

被引：84

作者：

Beatty, GL ^{[1
]}

Paterson, Y ^{[1
]}

机构：

[1] Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USA

来源：

IMMUNOLOGIC RESEARCH | 2001年 / 24卷 / 02期

关键词：

immunotherapy; IFN-gamma; IFN-gamma receptor; angiogenesis; tumor associated antigen; T cells;

D O I：

10.1385/IR:24:2:201

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tumor immunity involves a concerted interplay between cytokines and effector cells. Extensive efforts have focused on understanding the roles of cytokines and their interactions with effector cells for the production of effective tumor immunity. One cytokine that is well recognized to play a central role in coordinating tumor immune responses is IFN-gamma. IFN-gamma exerts its biological effects through interaction with an IFN-gamma receptor that is ubiquitously expressed on nearly all cells. In this review, we discuss the positive and negative effects of IFN-gamma signaling in the tumor cell on tumor growth.

引用

页码：201 / 210

页数：10

共 75 条

[1] Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases [J].