T lymphocytes as dynamic regulators of glioma pathobiology

被引：31

作者：

Cordell, Elizabeth C. ^{[1
]}

Alghamri, Mahmoud S. ^{[2
,3
,4
]}

Castro, Maria G. ^{[2
,3
]}

Gutmann, David H. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Neurol, Box 8111,660 South Euclid Ave, St Louis, MO 63110 USA

[2] Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA

[4] Boehringer Ingelheim Inc, Ridgefield, CT USA

来源：

NEURO-ONCOLOGY | 2022年 / 24卷 / 10期

基金：

美国国家卫生研究院;

关键词：

astrocytoma; glioblastoma; gliomagenesis; microglia; pediatric low-grade glioma; T cells; tumor microenvironment; tumor-associated monocytes; PEDIATRIC BRAIN-TUMORS; CHECKPOINT BLOCKADE; ADAPTIVE TOLERANCE; CELL EXHAUSTION; GLIOBLASTOMA; CANCER; SURVIVAL; RECRUITMENT; EXPRESSION; MICROENVIRONMENT;

D O I：

10.1093/neuonc/noac055

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The brain tumor microenvironment contains numerous distinct types of nonneoplastic cells, which each serve a diverse set of roles relevant to the formation, maintenance, and progression of these central nervous system cancers. While varying in frequencies, monocytes (macrophages, microglia, and myeloid-derived suppressor cells), dendritic cells, natural killer cells, and T lymphocytes represent the most common nonneoplastic cellular constituents in low- and high-grade gliomas (astrocytomas). Although T cells are conventionally thought to target and eliminate neoplastic cells, T cells also exist in other states, characterized by tolerance, ignorance, anergy, and exhaustion. In addition, T cells can function as drivers of brain cancer growth, especially in low-grade gliomas. Since T cells originate in the blood and bone marrow sinuses, their capacity to function as both positive and negative regulators of glioma growth has ignited renewed interest in their deployment as immunotherapeutic agents. In this review, we discuss the roles of T cells in low- and high-grade glioma formation and progression, as well as the potential uses of modified T lymphocytes for brain cancer therapeutics.

引用

页码：1647 / 1657

页数：11

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