TRPV1: Structure, Endogenous Agonists, and Mechanisms

被引：101

作者：

Benitez-Angeles, Miguel ^{[1
]}

Luz Morales-Lazaro, Sara ^{[1
]}

Juarez-Gonzalez, Emmanuel ^{[1
]}

Rosenbaum, Tamara ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Div Neurociencias, Dept Neurociencia Cognit, Mexico City 04510, DF, Mexico

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 10期

关键词：

TRP channels; TRPV1; pain; agonist; structure; POLYUNSATURATED FATTY-ACIDS; VANILLOID RECEPTOR TRPV1; CAPSAICIN RECEPTOR; CHANNEL ACTIVATION; HYDROGEN-SULFIDE; SENSORY NEURONS; ION-CHANNEL; SYNAPTIC-TRANSMISSION; N-OLEOYLETHANOLAMIDE; PHOSPHOLIPASE-D;

D O I：

10.3390/ijms21103421

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is a polymodal protein with functions widely linked to the generation of pain. Several agonists of exogenous and endogenous nature have been described for this ion channel. Nonetheless, detailed mechanisms and description of binding sites have been resolved only for a few endogenous agonists. This review focuses on summarizing discoveries made in this particular field of study and highlighting the fact that studying the molecular details of activation of the channel by different agonists can shed light on biophysical traits that had not been previously demonstrated.

引用

页数：18

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