Safe and effective induction therapy with CHASER for primary testicular lymphoma with central nervous system involvement

被引：0

作者：

Sunami, Yoshitaka ^{[1
]}

Ichikawa, Kunimoto ^{[2
]}

Edahiro, Yoko ^{[1
]}

Komatsu, Norio ^{[1
]}

Koike, Michiaki ^{[3
]}

机构：

[1] Juntendo Univ, Sch Med, Dept Hematol, Tokyo 113, Japan

[2] Shibanishi Clin, Saitama, Japan

[3] Juntendo Shizuoka Hosp, Dept Hematol, Shizuoka, Japan

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 09期

关键词：

Primary testicular lymphoma; CHASER therapy; non-hodgkin's lymphoma; diffuse large b-cell lymphoma; central nerve system involvement; NON-HODGKINS-LYMPHOMA; HIGH-DOSE CYTARABINE; B-CELL LYMPHOMA; CNS PROPHYLAXIS; PHASE-II; RITUXIMAB; CYCLOPHOSPHAMIDE; DEXAMETHASONE; IRRADIATION; ETOPOSIDE;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Primary testicular lymphoma (PTL) is a rare, aggressive form of non-Hodgkin's lymphoma (NHL) with a poor prognosis. The standard treatment strategy for cases of PTL with advanced stage at diagnosis, especially those with central nervous system (CNS) involvement, remains to be established. Here, we report the case of a 63-year-old Japanese man who developed PTL with CNS involvement, and was safely and effectively treated with CHASER (cyclophosphamide, high-dose cytarabine, dexamethasone, etoposide, and rituximab). CHASER led to the improvement of the neurological symptoms, and no signs of lymphoma were detected by fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT), including in the cerebrospinal fluid. In addition, peripheral blood stem cell harvest was successfully completed after four courses of CHASER. The present case suggests the possibility of CHASER as a safe and effective induction therapy for advanced NHL with CNS involvement at diagnosis.

引用

页码：18645 / 18649

页数：5

共 10 条

[1] Central nervous system recurrence of systemic lymphoma in the era of stem cell transplantation - an International Primary Central Nervous System Lymphoma Study Group project [J].

Bromberg, Jacoline E. ;

Doorduijn, Jeanette K. ;

Illerhaus, Gerald ;

Jahnke, Kristoph ;

Korfel, Agniezka ;

Fischer, Lars ;

Fritsch, Kristina ;

Kuittinen, Outti ;

Issa, Samar ;

van Montfort, Cees ;

van den Bent, Martin J. .

HAEMATOLOGICA, 2013, 98 (05) :808-813

[2] High-dose cytarabine plus high-dose methotrexate versus high-dose methotrexate alone in patients with primary CNS lymphoma: a randomised phase 2 trial [J].

Ferreri, Andres J. M. ;

Reni, Michele ;

Foppoli, Marco ;

Martelli, Maurizio ;

Pangalis, Gerasimus A. ;

Frezzato, Maurizio ;

Cabras, Maria Giuseppina ;

Fabbri, Alberto ;

Corazzelli, Gaetano ;

Ilariucci, Fiorella ;

Rossi, Giuseppe ;

Soffietti, Riccardo ;

Stelitano, Caterina ;

Vallisa, Daniele ;

Zaja, Francesco ;

Zoppegno, Lucia ;

Aondio, Gian Marco ;

Avvisati, Giuseppe ;

Balzarotti, Monica ;

Brandes, Alba A. ;

Fajardo, Jose ;

Gomez, Henry ;

Guarini, Attilio ;

Pinotti, Graziella ;

Rigacci, Luigi ;

Uhlmann, Catrina ;

Picozzi, Piero ;

Vezzulli, Paolo ;

Ponzoni, Maurilio ;

Zucca, Emanuele ;

Caligaris-Cappio, Federico ;

Cavalli, Franco .

LANCET, 2009, 374 (9700) :1512-1520

[3] Management and prognosis of 66 patients with B-cell non-Hodgkin lymphoma presenting with initial spinal cord compression: a French retrospective multicenter study [J].

Fleury, Isabelle ;

Amorim, Sandy ;

Mounier, Nicolas ;

Coiffier, Bertrand ;

Dupuis, Jehan ;

Tilly, Herve ;

Mazari, Mohamed A. ;

Filliatre, Lauriane ;

Briere, Josette ;

Brice, Pauline ;

de Kerviler, Eric ;

Thieblemont, Catherine .

LEUKEMIA & LYMPHOMA, 2015, 56 (07) :2025-2031

[4] Lymphomatoid Granulomatosis with Central Nervous System Involvement Successfully Treated with Cyclophosphamide, High-dose Cytarabine, Dexamethasone, Etoposide, and Rituximab (CHASER therapy) Followed by Brain Irradiation: A Case Study [J].

Fujimaki, Motoki ;

Kawajiri, Sumihiro ;

Ichikawa, Kunimoto ;

Tomizawa, Yuji ;

Nakazato, Tomoko ;

Noda, Kazuyuki ;

Hattori, Nobutaka ;

Koike, Michiaki ;

Okuma, Yasuyuki .

CNS NEUROSCIENCE & THERAPEUTICS, 2015, 21 (07) :610-612

[5] High incidence of occult leptomeningeal disease detected by flow cytometry in newly diagnosed aggressive B-cell lymphomas at risk for central nervous system involvement: the role of flow cytometry versus cytology [J].

Hegde, U ;

Filie, A ;

Little, RF ;

Janik, JE ;

Grant, N ;

Steinberg, SM ;

Dunleavy, K ;

Jaffe, ES ;

Abati, A ;

Stetler-Stevenson, M ;

Wilson, WH .

BLOOD, 2005, 105 (02) :496-502

[6] NOA-03 trial of high-dose methotrexate in primary central nervous system lymphoma:: Final report [J].

Herrlinger, U ;

Küker, W ;

Uhl, M ;

Blaicher, HP ;

Karnath, HO ;

Kanz, L ;

Bamberg, M ;

Weller, M .

ANNALS OF NEUROLOGY, 2005, 57 (06) :843-847

[7] SYSTEMIC HIGH-DOSE ARA-C FOR THE TREATMENT OF MENINGEAL LEUKEMIA IN ADULT ACUTE LYMPHOBLASTIC-LEUKEMIA AND NON-HODGKINS-LYMPHOMA [J].

MORRA, E ;

LAZZARINO, M ;

INVERARDI, D ;

BRUSAMOLINO, E ;

ORLANDI, E ;

CANEVARI, A ;

PAGNUCCO, G ;

BERNASCONI, C .

JOURNAL OF CLINICAL ONCOLOGY, 1986, 4 (08) :1207-1211

[8] Phase II study of a salvage regimen using cyclophosphamide, high-dose cytarabine, dexamethasone, etoposide, and rituximab in patients with relapsed or refractory B-cell non-Hodgkin's lymphoma [J].

Oki, Yasuhiro ;

Ogura, Michinori ;

Kato, Harumi ;

Kikuchi, Ako ;

Taji, Hirofumi ;

Kagami, Yoshitoyo ;

Oshiro, Aya ;

Tsujimura, Akane ;

Yamamoto, Kazuhito ;

Morishima, Yasuo .

CANCER SCIENCE, 2008, 99 (01) :179-184

[9] CNS prophylaxis in diffuse large B-cell lymphoma: If, when, how and for whom? [J].

Siegal, Tali ;

Goldschmidt, Neta .

BLOOD REVIEWS, 2012, 26 (03) :97-106

[10] First-Line Treatment for Primary Testicular Diffuse Large B-Cell Lymphoma With Rituximab-CHOP, CNS Prophylaxis, and Contralateral Testis Irradiation: Final Results of an International Phase II Trial [J].

Vitolo, Umberto ;

Chiappella, Annalisa ;

Ferreri, Andres J. M. ;

Martelli, Maurizio ;

Baldi, Ileana ;

Balzarotti, Monica ;

Bottelli, Chiara ;

Conconi, Annarita ;

Gomez, Henry ;

Lopez-Guillermo, Armando ;

Martinelli, Giovanni ;

Merli, Francesco ;

Novero, Domenico ;

Orsucci, Lorella ;

Pavone, Vincenzo ;

Ricardi, Umberto ;

Storti, Sergio ;

Gospodarowicz, Mary K. ;

Cavalli, Franco ;

Sarris, Andreas H. ;

Zucca, Emanuele .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (20) :2766-2772

← 1 →