Finding transcriptional regulatory elements in Dictyostelium gene expression

被引：0

作者：

Seo, D ^{[1
]}

Yasunaga, M ^{[1
]}

Kim, IS ^{[1
]}

Ham, BW ^{[1
]}

Kim, JH ^{[1
]}

机构：

[1] Univ Arkansas, Dept Appl Sci, Little Rock, AR 72204 USA

来源：

2005 IEEE CONGRESS ON EVOLUTIONARY COMPUTATION, VOLS 1-3, PROCEEDINGS | 2005年

关键词：

D O I：

暂无

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

In this paper, we proposed an improved method in the prediction of stage-specific TREs associated with four classes of developmentally regulated genes in Dictyostelium discoideum. TRE selection with a direct comparison of E-scores produced lots of the false positive results. In order to reduce false-positive prediction, we applied a normalization method to E-scores and predicted TREs in each developmentally regulated Dd gene sequence. Among the top 25 putative TREs in Vegetative and Culmination stage, we found two experimentally known TREs out of 6 known TREs in the TRANSFAC database. We also predicted five TREs experimentally known from the literature in the simulation results.

引用

页码：1746 / 1752

页数：7

共 35 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].