A Library of Conformationally Restricted Saturated Heterocyclic Sulfonyl Chlorides

被引：10
作者：
Zhersh, Sergey [1 ,2 ]
Buryanov, Volodymyr V. [1 ,2 ]
Karpenko, Oleksandr V. [1 ]
Grygorenko, Oleksandr O. [1 ,2 ]
Tolmachev, Andrey A. [1 ,2 ]
机构：
[1] Enamine Ltd, UA-01103 Kiev, Ukraine
[2] Kyiv Natl Taras Shevchenko Univ, Dept Chem, UA-01033 Kiev, Ukraine
来源：
SYNTHESIS-STUTTGART | 2011年 / 22期
关键词：
sulfonyl chlorides; nitrogen heterocycles; molecular rigidity; libraries; conformational restriction; INHIBITORS; ACID; DESIGN; PEPTIDOSULFONAMIDES; PEPTIDOMIMETICS; SULFINAMIDE; DERIVATIVES; DIVERSITY; PEPTIDES; REAGENTS;
D O I：
10.1055/s-0030-1260223
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An approach to the synthesis of conformationally restricted saturated heterocyclic sulfonyl chlorides is described. Being guided by the principle of diversity-oriented conformational restriction, a mini-library of saturated heterocyclic sulfonyl chlorides was designed and synthesized. The library consists of nine members that are derivatives of azetidine, pyrrolidine, and piperidine. These compounds were prepared in 19-88% total yields on multigram scale starting from the corresponding Cbz-protected amino alcohols.
引用
收藏
页码：3669 / 3674
页数：6
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