Copper-catalyzed asymmetric propargylic substitution reactions of propargylic acetates with amines

被引：195

作者：

Hattori, Gaku ^{[1
]}

Matsuzawa, Hiroshi ^{[1
]}

Miyake, Yoshihiro ^{[1
]}

Nishibayashi, Yoshiaki ^{[1
]}

机构：

[1] Univ Tokyo, Sch Engn, Inst Engn Innovat, Bunkyo Ku, Tokyo 1138656, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 20期

关键词：

amination; asymmetric catalysis; copper; nucleophilic substitution; P ligands;

D O I：

10.1002/anie.200800276

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Flexing your bipheps: Enantioselective propargylic substitution reactions of propargylic acetates with amines catalyzed by a copper-(R)-Cl-MeO-biphep or -binap complex give the corresponding propargylic amines in excellent yields with up to 89% ee. The reaction described may provide a novel synthetic method for the preparation of chiral propargylic amines. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3781 / 3783

页数：3

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