COVID-19 vulnerability: the potential impact of genetic susceptibility and airborne transmission

被引：91

作者：

Godri Pollitt, Krystal J. ^{[1
]}

Peccia, Jordan ^{[2
]}

Ko, Albert I. ^{[3
]}

Kaminski, Naftali ^{[4
]}

Dela Cruz, Charles S. ^{[4
]}

Nebert, Daniel W. ^{[5
,6
]}

Reichardt, Juergen K. V. ^{[7
]}

Thompson, David C. ^{[8
]}

Vasiliou, Vasilis ^{[1
]}

机构：

[1] Yale Univ, Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT 06510 USA

[2] Yale Univ, Sch Engn & Appl Sci, Dept Chem & Environm Engn, New Haven, CT 06520 USA

[3] Yale Univ, Sch Publ Hlth, Dept Epidemiol Microbial Dis, New Haven, CT 06510 USA

[4] Yale Univ, Sch Med, Sect Pulm Crit Care & Sleep Med, 333 Cedar St, New Haven, CT 06520 USA

[5] Univ Cincinnati, Med Ctr, Dept Environm Hlth, Cincinnati, OH 45267 USA

[6] Univ Cincinnati, Med Ctr, Ctr Environm Genet, Cincinnati, OH 45267 USA

[7] James Cook Univ, Australian Inst Trop Hlth & Med, Smithfield, Qld, Australia

[8] Univ Colorado Denver, Skaggs Sch Pharm & Pharmaceut Sci, Dept Clin Pharm, Aurora, CO 80045 USA

来源：

HUMAN GENOMICS | 2020年 / 14卷 / 01期

关键词：

ACUTE RESPIRATORY SYNDROME; INFECTIOUS AGENTS; CORONAVIRUS; ACE2; VENTILATION; ENVIRONMENT; FILTRATION; OUTBREAK; RECEPTOR; AIR;

D O I：

10.1186/s40246-020-00267-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The recent coronavirus disease (COVID-19), caused by SARS-CoV-2, is inarguably the most challenging coronavirus outbreak relative to the previous outbreaks involving SARS-CoV and MERS-CoV. With the number of COVID-19 cases now exceeding 2 million worldwide, it is apparent that (i) transmission of SARS-CoV-2 is very high and (ii) there are large variations in disease severity, one component of which may be genetic variability in the response to the virus. Controlling current rates of infection and combating future waves require a better understanding of the routes of exposure to SARS-CoV-2 and the underlying genomic susceptibility to this disease. In this mini-review, we highlight possible genetic determinants of COVID-19 and the contribution of aerosol exposure as a potentially important transmission route of SARS-CoV-2.

引用

页数：7

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