Synthesis of pyrrolopyrimidine CRF-R1 antagonists containing a tricyclic core via an intramolecular heck reaction

被引：4
|
作者：
Dyck, B [1 ]
McCarthy, JR [1 ]
机构：
[1] Neurocrine Biosci Inc, Dept Med Chem, San Diego, CA 92121 USA
来源：
HETEROCYCLES | 2004年 / 62卷
关键词：
corticotropin-releasing factor (hormone); fused pyrimidine; anxiety; depression;
D O I：
10.3987/COM-03-S(P)41
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A synthetic route to pharmaceutically important tricyclic pyrrolopyrimidines was developed. The method employs a palladium-mediated Heck cyclization as the critical step in the construction of the final six membered ring.
引用
收藏
页码：191 / 195
页数：5
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