Leccinine A, an endoplasmic reticulum stress-suppressive compound from the edible mushroom Leccinum extremiorientale

被引：21
作者：
Choi, Jae-Hoon [1 ]
Ozawa, Nobuhiko [1 ]
Yamakawa, Yasuhiro [1 ]
Nagai, Kaoru [2 ]
Hirai, Hirofumi [1 ]
Kawagishi, Hirokazu [1 ,3 ]
机构：
[1] Shizuoka Univ, Fac Agr, Dept Appl Biol Chem, Suruga Ku, Shizuoka 4228529, Japan
[2] Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Epigenet Med, Yamanashi 4093898, Japan
[3] Shizuoka Univ, Grad Sch Sci & Technol, Suruga Ku, Shizuoka 4228529, Japan
来源：
TETRAHEDRON | 2011年 / 67卷 / 35期
关键词：
Endoplasmic reticulum stress suppression; Mushroom; Leccinum extremiorientale; Structural determination; ER STRESS; HERICIUM-ERINACEUM; CELL-DEATH; CASPASE-12; TUNICAMYCIN; ACTIVATION; APOPTOSIS; PATHWAY;
D O I：
10.1016/j.tet.2011.05.052
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Leccinine A (1) along with a known compound (2), were isolated from the edible mushroom Leccinum extremiorientale. The structure of 1 was determined by the interpretation of spectral data. Leccinine A showed protective activity against endoplasmic reticulum stress-dependent cell death. Seven analogues (3-9) of 1 were synthesized in order to evaluate the structure-activity relationship, and the result indicated that the formamide group of 1 was indispensable for the activity. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6649 / 6653
页数：5
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