共 50 条
Drosophila Studies on Autism Spectrum Disorders
被引:29
作者:
Tian, Yao
[1
]
Zhang, Zi Chao
[1
]
Han, Junhai
[1
]
机构:
[1] Southeast Univ, Inst Life Sci, Key Lab Dev Genes & Human Dis, Nanjing 210096, Jiangsu, Peoples R China
基金:
中国国家自然科学基金;
关键词:
Autism spectrum disorders;
Drosophila;
Chromatin remodeling;
Synaptic scaffolding;
Synaptic transmission;
MENTAL-RETARDATION PROTEIN;
FRAGILE-X PROTEIN;
SYNAPTIC GROWTH;
INTELLECTUAL DISABILITY;
NEUROBEACHIN GENE;
REGULATES SLEEP;
MESSENGER-RNAS;
EXPRESSION;
CHILDREN;
RECEPTOR;
D O I:
10.1007/s12264-017-0166-6
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
In the past decade, numerous genes associated with autism spectrum disorders (ASDs) have been identified. These genes encode key regulators of synaptogenesis, synaptic function, and synaptic plasticity. Drosophila is a prominent model system for ASD studies to define novel genes linked to ASDs and decipher their molecular roles in synaptogenesis, synaptic function, synaptic plasticity, and neural circuit assembly and consolidation. Here, we review Drosophila studies on ASD genes that regulate synaptogenesis, synaptic function, and synaptic plasticity through modulating chromatin remodeling, transcription, protein synthesis and degradation, cytoskeleton dynamics, and synaptic scaffolding.
引用
收藏
页码:737 / 746
页数:10
相关论文
共 50 条