Solute carrier transporters: emerging central players in tumour immunotherapy

被引：35

作者：

Chen, Ruiqun ^{[1
]}

Chen, Ligong ^{[1
,2
,3
]}

机构：

[1] Tsinghua Univ, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Sch Pharmaceut Sci, Beijing 100084, Peoples R China

[2] Sichuan Univ, West China Med Sch, West China Hosp, Collaborat Innovat Ctr Biotherapy,State Key Lab B, Chengdu 610065, Peoples R China

[3] Sichuan Univ, West China Hosp, Canc Ctr, West China Med Sch, Chengdu 610065, Peoples R China

来源：

TRENDS IN CELL BIOLOGY | 2022年 / 32卷 / 03期

基金：

中国国家自然科学基金;

关键词：

T-CELL METABOLISM; GLUCOSE-METABOLISM; ACID-TRANSPORT; REGULATORY T; ACTIVATION; SUPPORTS; MACROPHAGES; IMMUNITY; SURVIVAL; DRIVES;

D O I：

10.1016/j.tcb.2021.08.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Solute carrier transporters (SLCs) mediate nutrient and metabolite cellular homeostasis. Immune cells depend on SLCs to induce rapid and robust meta-bolic reprogramming, thereby controlling diverse immunological responses. Recent studies hint toward an important role of SLCs in immunity. Here, we review the emerging roles of SLCs in immunotherapy via modifying the metabolism and effector functions of immune cells. We focus on the roles of three major nutrient (glucose, amino acid, and lipid)-related transporters in immunity of representative cells [T cells, dendritic cells (DCs), natural killer (NK) cells, and macrophages) in innate and adaptive immunity. Other SLCs, such as ion trans-porters are also briefly discussed. Finally, we propose some potential strategies for targeting SLCs to augment tumour immunotherapy.

引用

页码：186 / 201

页数：16

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