Factors Associated with Medication Adherence in Patients with Chronic Obstructive Pulmonary Disease

被引:113
作者
Agh, Tamas [1 ]
Inotai, Andras [1 ]
Meszaros, Agnes [1 ]
机构
[1] Semmelweis Univ, Univ Pharm Dept Pharm Adm, HU-1092 Budapest, Hungary
关键词
Chronic obstructive pulmonary disease; Medication adherence; Respiratory therapy; Quality of life; QUALITY-OF-LIFE; RESPIRATORY DRUGS; COPD PATIENTS; PERSISTENCE; THERAPY; ASTHMA;
D O I
10.1159/000324453
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background: Predictors of medication adherence are not well known in chronic obstructive pulmonary disease (COPD). It is therefore necessary to identify factors associated with adherence to improve the effectiveness of COPD management within real-world situations. Objectives: The goals of this study were to estimate adherence to respiratory medication and to identify factors related to adherence in COPD patients. Methods: This was an observational, cross-sectional study conducted on a sample of COPD outpatients. The following information was obtained: adherence to respiratory therapy (Morisky Medication Adherence Scale), age, gender, smoking status, COPD severity [Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage], lung function [post-bronchodilator forced expiratory volume in 1 s (FEV1)], treatment regimen for COPD, COPD medication costs per month paid by the patient and health-related quality of life (EuroQol 5-dimension questionnaire). A multivariate logistic regression analysis was performed to identify the independent predictors of adherence. Results: Of the 170 participants (mean age 63.8 years, 41.8% male), 58.2% reported optimal adherence. Adherence to respiratory therapy was associated with age, current smoking status, number of respiratory drugs, number of daily respiratory drug doses and quality of life (p < 0.005). Adherence to respiratory therapy was not related to gender, GOLD stage, FEV1 or COPD medication costs. Conclusions: Adherence to COPD medication regimens is poor. Less frequent dosing regimens could be an effective method to enhance adherence to respiratory therapy. Quality-of-life monitoring within clinical practice settings could facilitate improved medication adherence. Copyright (C) 2011 S. Karger AG, Basel
引用
收藏
页码:328 / 334
页数:7
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