Potent suppressive effects of urocortin on splenic lymphocyte activity in rats

被引：22

作者：

Okamoto, S ^{[1
]}

Ishikawa, I ^{[1
]}

Kimura, K ^{[1
]}

Saito, M ^{[1
]}

机构：

[1] Hokkaido Univ, Sch Vet Med, Dept Biomed Sci, Biochem Lab, Sapporo, Hokkaido 0600818, Japan

来源：

NEUROREPORT | 1998年 / 9卷 / 18期

关键词：

CRF; immunosuppression; lymphocyte; sympathetic nerves; urocortin;

D O I：

10.1097/00001756-199812210-00009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To assess the possible role of urocortin, a recently identified neuropeptide related to corticotropin-releasing factor (CRF), in modulation of peripheral immune functions, the effects of intracranially administrated urocortin on the proliferative activity of splenic lymphocytes were examined in rats; Intracerebroventricular (i.c.v.) injection of urocortin (1 ng) produced a marked decrease in the proliferative response of splenocytes to a mitogen. The suppressive effect of urocortin was abolished by pretreatment with a ganglionic blocking agent (chlorisondamine) or a beta-adrenergic receptor antagonist (propranolol), but not by adrenalectomy. These results suggest that urocortin is an important neuropeptide involved in the brain control of peripheral immune functions such as stress-induced immunosuppression, and that the suppressive effect of urocortin is mediated by the sympathetic nervous system. (C) 1998 Lippincott Williams & Wilkins.

引用

页码：4035 / 4039

页数：5

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