Synthesis and Anti-thyroid Cancer Effect of Iodo-chrysin Derivatives

被引：5

作者：

Wei, Yun ^{[1
,2
]}

Zheng, Qutong ^{[1
,2
]}

Tang, Guotao ^{[1
,2
]}

Song, Chen ^{[1
,2
,3
]}

Wang, Guan ^{[1
,2
,3
]}

Zhang, Yinxiang ^{[1
,2
,3
]}

Xiao, Yan ^{[1
,2
]}

Zeng, Xianliang ^{[1
,2
]}

Wang, Zongbao ^{[1
,2
]}

Xiao, Jichang ^{[2
,4
]}

Zheng, Xing ^{[1
,2
]}

机构：

[1] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China

[2] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China

[3] Univ South China, Res Interest Grp Pharm, Hengyang 421001, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

MEDICINAL CHEMISTRY | 2016年 / 12卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Anti-thyroid cancer; activities; Baker-Venkataraman reaction; flavonoids; iodo-chrysin derivatives; MTT method; THYROID-CANCER; INHIBITION; FLAVONOIDS; GROWTH; CELLS;

D O I：

10.2174/1573406411666150921111220

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of iodo-chrysin derivatives with resorcinol as raw materials were synthesized according to Baker-Venkataraman reaction and their inhibitory activities in vitro against thyroid cancer cell lines (SW-579 and TT) were evaluated by the standard methyl thiazole tetrazolium (MTT) method. Biological test results showed that these derivatives possessed stronger anti-thyroid cancer activities than 5-FU. Compound 21 showed the strongest activity against SW-579 cell lines with IC50 value of 3.4 mu M and compound 10 showed the strongest activity against TT cell lines with IC50 value of 6.2 mu M, it was better than 5-FU (59.3 mu M, 18.4 mu M respectively).

引用

页码：441 / 447

页数：7

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