Unraveling the Biological Roles of Reactive Oxygen Species

被引：636

作者：

Murphy, Michael P. ^{[1
]}

Holmgren, Arne ^{[2
]}

Larsson, Nils-Goeran ^{[3
]}

Halliwell, Barry ^{[4
]}

Chang, Christopher J. ^{[5
,6
]}

Kalyanaraman, Balaraman ^{[7
,8
]}

Rhee, Sue Goo ^{[9
]}

Thornalley, Paul J. ^{[10
]}

Partridge, Linda ^{[11
]}

Gems, David ^{[11
]}

Nystrom, Thomas ^{[12
]}

Belousov, Vsevolod ^{[13
]}

Schumacker, Paul T. ^{[14
]}

Winterbourn, Christine C. ^{[15
]}

机构：

[1] MRC Mitochondrial Biol Unit, Cambridge CB2 0XY, England

[2] Karolinska Inst, Dept Med Biochem & Biophys, SE-17177 Stockholm, Sweden

[3] Max Planck Inst Biol Ageing, D-50931 Cologne, Germany

[4] Natl Univ Singapore, Singapore 119077, Singapore

[5] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[6] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA

[7] Med Coll Wisconsin, Dept Biophys, Milwaukee, WI 53226 USA

[8] Med Coll Wisconsin, Free Rad Res Ctr, Milwaukee, WI 53226 USA

[9] Ewha Womans Univ, Div Life & Pharmaceut Sci, Seoul 120750, South Korea

[10] Univ Warwick, Univ Hosp, Clin Sci Res Inst, Coventry CV2 2DX, W Midlands, England

[11] UCL, Inst Healthy Ageing, Dept Genet Evolut & Environm, London WC1E 6BT, England

[12] Gothenburg Univ, S-40530 Gothenburg, Sweden

[13] Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

[14] Northwestern Univ, Chicago, IL 60611 USA

[15] Univ Otago, Dept Pathol, Christchurch 8011, New Zealand

来源：

CELL METABOLISM | 2011年 / 13卷 / 04期

基金：

英国生物技术与生命科学研究理事会;

关键词：

IN-VIVO; HYDROGEN-PEROXIDE; N-ACETYLCYSTEINE; OXIDATIVE STRESS; FLUORESCENT; SUPEROXIDE; CELLS; ISOTHIOCYANATE; MITOCHONDRIA; MUTATIONS;

D O I：

10.1016/j.cmet.2011.03.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reactive oxygen species are not only harmful agents that cause oxidative damage in pathologies, they also have important roles as regulatory agents in a range of biological phenomena. The relatively recent development of this more nuanced view presents a challenge to the biomedical research community on how best to assess the significance of reactive oxygen species and oxidative damage in biological systems. Considerable progress is being made in addressing these issues, and here we survey some recent developments for those contemplating research in this area.

引用

页码：361 / 366

页数：6

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