Aging and its treatment with vitamin C: a comprehensive mechanistic review

被引：33

作者：

Mumtaz, Shumaila ^{[1
]}

Ali, Shaukat ^{[1
]}

Tahir, Hafiz Muhammad ^{[1
]}

Kazmi, Syed Akif Raza ^{[2
]}

Shakir, Hafiz Abdullah ^{[3
]}

Mughal, Tafail Akbar ^{[1
]}

Mumtaz, Samaira ^{[1
]}

Summer, Muhammad ^{[1
]}

Farooq, Muhammad Adeel ^{[1
]}

机构：

[1] Govt Coll Univ, Dept Zool, Appl Entomol & Med Toxicol & Lab, Lahore, Pakistan

[2] Govt Coll Univ, Dept Chem, Lahore, Pakistan

[3] Univ Punjab, Inst Zool, Lahore, Pakistan

来源：

MOLECULAR BIOLOGY REPORTS | 2021年 / 48卷 / 12期

关键词：

Aging; Oxidative stress; Reactive oxygen species (ROS); Age-related disorders; vitamin C; Antioxidant; OXIDATIVE STRESS; ASCORBIC-ACID; ANTIOXIDANT; PRODUCTS; DISEASE; CELLS; SKIN;

D O I：

10.1007/s11033-021-06781-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aging and age-related disorders have become one of the prominent issue of world. Oxidative stress due to overproduction of reactive oxygen species is the most significant cause of aging. The aim of literature compilation was to elucidate the therapeutic effect of vitamin C against oxidative stress. Various mediators with anti-inflammatory and anti-oxidant properties might be probable competitors of vitamin C for the improvement of innovative anti-aging treatments. More attention has been paid to vitamin C due to its anti-oxidant property and potentially beneficial biological activities for inhibiting aging.Vitamin C acts as an antioxidant agent and free radical scavenger that can protect the cell from oxidative stress, disorganization of chromatin, telomere attrition, and prolong the lifetime. This review emphasizes mechanism of aging and various biomarkers that are directly related to aging and also focuses on the therapeutic aspect of vitamin C against oxidative stress and age-related disorders.

引用

页码：8141 / 8153

页数：13

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