PHARMACEUTICAL ANALYSIS AND STANDARDIZATION OF AFOBAZOLE IN SOLID DOSAGE FORM (TABLETS)

被引：0

作者：

Grushevskaya, L. N. ^{[1
]}

Milkina, S. E. ^{[2
]}

Stepanenko, O. B. ^{[1
]}

Volkova, M. Yu. ^{[1
]}

Pyatin, B. M. ^{[1
]}

Avdyunina, N. I. ^{[1
]}

Alekseev, K. V. ^{[1
]}

Sizyakov, S. A. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Zakusov State Inst Pharmacol, Moscow, Russia

[2] Sci Ctr Expertise Med Prod, Fed Serv Russian Federat Supervis Sphere Publ Hlt, Moscow, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2010年 / 44卷 / 09期

关键词：

afobazole; tablets; pharmaceutical analysis;

D O I：

10.1007/s11094-010-0507-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The investigation was aimed at developing procedures for the pharmaceutical analysis and standardization of the new domestic anxiolytic afobazole in solid dosage form (tablets). The main pharmacopoeial tests have been carried out and methods for the determination (TLC, HPLC), identification (TLC, UV spectrophotometry), and quantitative assay (UV spectrophotometry, HPLC) have been worked out. The test for uniformity of composition and the dissolution test were carried out with the aid of UV spectrophotometry.

引用

页码：517 / 520

页数：4

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