Impaired quality of life and sexual function in overweight and obese men: the European Male Ageing Study

被引:72
作者
Han, Thang S. [1 ]
Tajar, Abdelouahid [2 ]
O'Neill, Terence W. [2 ]
Jiang, Min [3 ]
Bartfai, Gyoergy [4 ]
Boonen, Steven [5 ,6 ]
Casanueva, Felipe [7 ]
Finn, Joseph D. [8 ]
Forti, Gianni [9 ]
Giwercman, Aleksander [10 ]
Huhtaniemi, Ilpo T. [11 ]
Kula, Krzysztof [12 ]
Pendleton, Neil [13 ]
Punab, Margus [14 ]
Silman, Alan J. [15 ]
Vanderschueren, Dirk [6 ,16 ]
Lean, Michael E. J. [17 ]
Wu, Frederick C. W. [8 ]
机构
[1] Univ Coll London Hosp, Sch Med, Dept Endocrinol, London, England
[2] Univ Manchester, Manchester Acad Hlth Sci Ctr, Epidemiol Unit, Arthrit Res UK, Manchester, Lancs, England
[3] Univ Turku, Dept Physiol, Turku, Finland
[4] Albert Szent Gyorgyi Med Univ, Dept Obstet Gynaecol & Androl, H-6701 Szeged, Hungary
[5] Katholieke Univ Leuven, Leuven Univ Div Geriatr Med, Leuven, Belgium
[6] Katholieke Univ Leuven, Leuven Univ Ctr Metab Bone Dis, Leuven, Belgium
[7] Univ Santiago de Compostela, Dept Med, CIBER Fisiopatol Obesidad & Nutr CB06 03, Inst Salud Carlos III,CHUS, Santiago De Compostela, Spain
[8] Univ Manchester, Manchester Royal Infirm, Manchester Acad Hlth Sci Ctr, Dept Endocrinol, Manchester M13 9WL, Lancs, England
[9] Univ Florence, Dept Clin Physiopathol, Androl Unit, Florence, Italy
[10] Lund Univ, Malmo Univ Hosp, Dept Urol, Scanian Androl Ctr, Lund, Sweden
[11] Univ London Imperial Coll Sci Technol & Med, Dept Reprod Biol, London, England
[12] Med Univ Lodz, Dept Androl & Reprod Endocrinol, Lodz, Poland
[13] Univ Manchester, Hope Hosp, Manchester Acad Hlth Sci Ctr, Salford M6 8HD, Lancs, England
[14] Tartu Univ Clin, United Labs, Androl Unit, Tartu, Estonia
[15] Arthrit Res UK, Chesterfield, England
[16] Katholieke Univ Leuven, Leuven Univ Div Endocrinol, Louvain, Belgium
[17] Univ Glasgow, Dept Human Nutr, Glasgow, Lanark, Scotland
关键词
CARDIOVASCULAR RISK-FACTORS; WAIST CIRCUMFERENCE; ABDOMINAL ADIPOSITY; UNITED-STATES; US ADULTS; ERECTILE DYSFUNCTION; ALL-CAUSE; TRENDS; PREVALENCE; MORTALITY;
D O I
10.1530/EJE-10-1129
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Few published data link overweight and obesity with measures of quality of life (QoL) including sexual health in men. Objective: To assess the association of overweight/obesity with impairment of physical and psychological QoL and sexual functions in men. Design and setting: Cross-sectional, multicentre survey of 3369 community-dwelling men aged 40-79 (mean +/- S.D., 60 +/- 11) years randomly selected from eight European centres. Outcomes: Adiposity was assessed by body mass index (BMI) and waist circumference (WC), QoL and functional impairments by physical and psychological function domains of the Short Form-36 questionnaire, Beck's Depression Inventory and the European Male Ageing Study sexual function questionnaire. Results: Complete data on sexual activities and erectile function were available in 2734 (92%) and 3193 (95%) of the participants respectively. From the population studied, 814 men were obese (BMI >= 30 kg/m(2)) and 1171 had WC >= 102 cm, 25% of all men were unable to do vigorous activity and 2-13% reported depressive symptoms. Symptoms of sexual dysfunction ranged between 22% (low sexual desire) and 40% (infrequent morning erections) of the participants. Among obese men with both BMI >= 30 kg/m(2) and WC >= 102 cm, at least one symptom of impaired physical, psychological and sexual function was reported by 41, 43 and 73% of the participants respectively. Compared with the reference group of non-obese men (BMI < 30 kg/m(2) and WC < 102cm), men with BMI >= 30 kg/m(2) and WC >= 102 cm more frequently reported at least one symptom of impaired physical function (odds ratio (OR)=2.67; confidence interval (CI): 2.07-3.45, P < 0.001), impaired psychological function (OR=1.48; CI: 1.14-1.90, P < 0.01) and impaired sexual function (OR=1.45; CI: 1.14-1.85, P < 0.01). These functional impairments were also more prevalent in men who had WC >= 102 cm even with BMI < 30 kg/m(2), but those with BMI >= 30 kg/m(2) and WC < 102 cm generally did not suffer from increased impaired physical or sexual health. Men with high BMI and WC were at even greater likelihood of having a composite of two or more or three or more symptoms compared with those with normal BMI and WC. Conclusions: Men with high WC, including those who are 'non-obese' with BMI < 30 kg/m(2), have poor QoL with symptoms of impaired physical, psychological and sexual functions. Health promotion to improve QoL should focus on prevention of obesity and central fat accumulation.
引用
收藏
页码:1003 / 1011
页数:9
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